Phospho-CBL (Y774) Recombinant Rabbit Monoclonal Antibody [JE62-93] (HA722786)

UNIPROT #

P22681

PROTEIN NAME

Phospho-CBL (Y774)

SYNONYMS

4732447J05Rik antibody;C CBL antibody;Cas Br M (murine) ecotropic retroviral transforming sequence antibody;Casitas B lineage lymphoma proto oncogene antibody;Casitas B-lineage lymphoma proto-oncogene antibody;CBL 2 antibody;cbl antibody;CBL_HUMAN antibody;CBL2 antibody;E3 ubiquitin protein ligase CBL antibody;E3 ubiquitin-protein ligase CBL antibody;Oncogene CBL2 antibody;Proto oncogene c CBL antibody;Proto-oncogene c-CBL antibody;RGD1561386 antibody;RING finger protein 55 antibody;RNF55 antibody;Signal transduction protein CBL antibody

SUBCELLULAR LOCATION

Cytoplasm, Cell membrane, Cell projection, cilium, Golgi apparatus.

FUNCTION

Cbl (named after Casitas B-lineage Lymphoma) is a mammalian gene family. CBL gene, a part of the Cbl family, encodes the protein CBL which is an E3 ubiquitin-protein ligase involved in cell signalling and protein ubiquitination. Mutations to this gene have been implicated in a number of human cancers, particularly acute myeloid leukaemia. Ubiquitination is the process of chemically attaching ubiquitin monomers to a protein, thereby targeting it for degradation. As this is a multi-step process, several different enzymes are involved, the final one being a member of the E3 family of ligases. Cbl functions as an E3 ligase, and therefore is able to catalyse the formation of a covalent bond between ubiquitin and Cbl's protein substrate - typically a receptor tyrosine kinase. The RING-finger domain mediates this transfer, however like other E3 ligases of the RING type no intermediate covalent bond is formed between ubiquitin and the RING-finger domain. The stepwise attachment of ubiquitin to the substrate receptor tyrosine kinase can lead to its removal from the plasma membrane and subsequent trafficking to the lysosome for degradation.