Phospho-Beclin 1 (S30) Recombinant Rabbit Monoclonal Antibody [PSH16-40] (HA723840)

UNIPROT #

Q14457

PROTEIN NAME

Phospho-Beclin 1 (S30)

SYNONYMS

APG6 antibody;ATG 6 antibody;ATG6 antibody;ATG6 autophagy related 6 homolog antibody;Bcl-2-interacting protein beclin antibody;Beclin 1 (coiled coil moesin like BCL2 interacting protein) antibody;Beclin 1 autophagy related antibody;Beclin-1 antibody;Beclin1 antibody;BECN 1 antibody;Becn1 antibody;BECN1_HUMAN antibody;Coiled coil myosin like BCL2 interacting protein antibody;Coiled-coil myosin-like BCL2-interacting protein antibody;GT197 antibody;Protein GT197 antibody;VPS 30 antibody;VPS30 antibody

SUBCELLULAR LOCATION

Cytoplasm, Golgi apparatus, trans-Golgi network membrane, Endosome membrane, Endoplasmic reticulum membrane, Mitochondrion membrane, Endosome, Cytoplasmic vesicle, autophagosome.

FUNCTION

Beclin-1 is a protein that in humans is encoded by the BECN1 gene. Beclin-1 is a mammalian ortholog of the yeast autophagy-related gene 6 (Atg6) and BEC-1 in the C. elegans nematode. This protein interacts with either BCL-2 or PI3k class III, playing a critical role in the regulation of both autophagy and cell death. Beclin-1 plays an important role in tumorigenesis, and neurodegeneration, being implicated in the autophagic programmed cell death. Ovarian cancer with upregulated autophagy has a less aggressive behavior and is more responsive to chemotherapy. Schizophrenia is associated with low levels of Beclin-1 in the hippocampus of those affected, which causes diminished autophagy which in turn results in increased neuronal cell death. This protein is thought to play a role in multiple cellular processes, including tumorigenesis, neurodegeneration and apoptosis. Alternative splicing results in multiple transcript variants.