Positive control:
Lane 1: SHG-44 cell lysate
Lane 2: A172 cell lysate
Applications
-
WB
-
ICC
-
IHC-P
-
FC
REACTIVITY
-
Human
-
Mouse
-
Rat
SPECIFICATIONS
Product Type
Rabbit polyclonal primary
Product Name
PGP9.5 Rabbit Polyclonal Antibody (R1511-8)
Immunogen
Peptide
Host
Rabbit
Positive Control
SHG-44 cell lysate, A172 cell lysate, N2A, human pancreas tissue, mouse pancreas tissue, SH-SY5Y.
Conjugation
Unconjugated
Clonality
Polyclonal
PROPERTIES
Form
Liquid
Storage Condition
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
Storage Buffer
1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1 ug/ul
PURIFICATION
Peptide affinity purified.
MOLECULAR WEIGHT
25 kDa
Isotype
IgG
TARGET
UNIPROT #
PROTEIN NAME
PGP9.5
SYNONYMS
Epididymis luminal protein 117 antibody; Epididymis secretory protein Li 53 antibody; HEL 117 antibody; HEL S 53 antibody; NDGOA antibody; Neuron cytoplasmic protein 9.5 antibody; OTTHUMP00000218137 antibody; OTTHUMP00000218139 antibody; OTTHUMP00000218140 antibody; OTTHUMP00000218141 antibody; Park 5 antibody; PARK5 antibody; PGP 9.5 antibody; PGP9.5 antibody; PGP95 antibody; Protein gene product 9.5 antibody; Ubiquitin C terminal esterase L1 antibody; Ubiquitin C terminal hydrolase antibody; Ubiquitin C terminal hydrolase L1 antibody; Ubiquitin carboxyl terminal esterase L1 antibody; Ubiquitin carboxyl terminal hydrolase isozyme L1 antibody; Ubiquitin carboxyl-terminal hydrolase isozyme L1 antibody; Ubiquitin thioesterase L1 antibody; Ubiquitin thiolesterase antibody; Ubiquitin thiolesterase L1 antibody; UCH-L1 antibody; UCHL1 antibody; UCHL1_HUMAN antibody
SEQUENCE SIMILARITIES
Belongs to the peptidase C12 family.
TISSUE SPECIFICITY
Found in neuronal cell bodies and processes throughout the neocortex (at protein level). Expressed in neurons and cells of the diffuse neuroendocrine system and their tumors. Weakly expressed in ovary. Down-regulated in brains from Parkinson disease and Alzheimer disease patients.
POST-TRANSLATIONAL MODIFICATION
O-glycosylated.
SUBCELLULAR LOCATION
Endoplasmic reticulum membrane, Cytoplasm.
FUNCTION
The protein encoded by this gene belongs to the peptidase C12 family. This enzyme is a thiol protease that hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. This gene is specifically expressed in the neurons and in cells of the diffuse neuroendocrine system. Mutations in this gene may be associated with Parkinson disease.