Perilipin A Recombinant Rabbit Monoclonal Antibody [JM10-96] (ET1703-38)

UNIPROT #

O60240

PROTEIN NAME

Perilipin A

SYNONYMS

Lipid droplet associated protein antibody;Lipid droplet-associated protein antibody;PERI antibody;Perilipin A antibody;Perilipin antibody;Perilipin-1 antibody;PerilipinA antibody;PLIN antibody;PLIN1 antibody;PLIN1_HUMAN antibody;Perilipin-1 antibody

SEQUENCE SIMILARITIES

Belongs to the perilipin family.

TISSUE SPECIFICITY

Detected in adipocytes from white adipose tissue (at protein level). Detected in visceral adipose tissue and mammary gland.

POST-TRANSLATIONAL MODIFICATION

Major cAMP-dependent protein kinase-substrate in adipocytes, also dephosphorylated by PP1. When phosphorylated, may be maximally sensitive to HSL and when unphosphorylated, may play a role in the inhibition of lipolysis, by acting as a barrier in lipid droplet (By similarity).

SUBCELLULAR LOCATION

Endoplasmic reticulum, Lipid droplet.

FUNCTION

Perilipin is a protein that coats lipid droplets (LDs) in adipocytes, the fat-storing cells in adipose tissue. In fact, PLIN1 is greatly expressed in white adipocytes.It controls adipocyte lipid metabolism. It handles essential functions in the regulation of basal and hormonally stimulated lipolysis and also rises the formation of large LDs which implies an increase in the synthesis of triglycerides.In humans, Perilipin A is the most abundant protein associated with the adipocyte LDs and lower PLIN1 expression is related with higher rates of lipolysis.Under basal conditions, Perilipin acts as a protective coating of LDs from the body's natural lipases, such as hormone-sensitive lipase (HSL) and adipose triglyceride lipase (ATGL), which break triglycerides into glycerol and free fatty acids for use in lipid metabolism.In times of energy deficit, Perilipin is hyperphosphorylated by PKA following β-adrenergic receptor activation. Phosphorylated perilipin changes conformation, exposing the stored lipids to hormone-sensitive lipase-mediated lipolysis.