PER1 Rabbit Polyclonal Antibody (HA500097)
Catalog# HA500097
Rabbit Polyclonal to PER1
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WB
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IHC-P
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IF-Tissue
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Human
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Mouse
Lane 1: Human HeLa cell lysates
Lane 2: Human A549 cell lysates
Primary: Anti-PER1 (bs-2350R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 136 kDa
Observed band size: 142 kDa
Specifications
Product Type
Rabbit polyclonal primary
Product Name
PER1 Rabbit Polyclonal Antibody (HA500097)
Immunogen
Klh conjugated synthetic peptide derived from human per1 protein: 751-850/1290
Host
Rabbit
Positive Control
Widely expressed. Found in heart, brain, placenta, lung, liver, skeletal muscle, pancreas, kidney, spleen, thymus, prostate, testis, ovary and small intestine. Highest level in skeletal muscle. Low level in kidney.
Conjugation
Unconjugated
Clonality
Polyclonal
RRID
APPLICATION DILUTION
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WB
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1:500-2000
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IHC-P
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1:100-500
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IF-tissue
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1:100-500
PROPERTIES
Form
Liquid
Storage Condition
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
Storage Buffer
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Concentration
1ug/ul
Purification
Protein A affinity purified.
Molecular Weight
Predicted band size: 136 kDa.
Isotype
IgG
TARGET
UNIPROT #
PROTEIN NAME
PER1
SYNONYMS
Circadian clock protein PERIOD 1 antibody;Circadian clock protein PERIOD1 antibody;Circadian pacemaker protein Rigui antibody;hPER 1 antibody;hPER antibody;hPER1 antibody;KIAA0482 antibody;MGC88021 antibody;PER 1 antibody;PER antibody;PER1 antibody;PER1 protein antibody;PER1_HUMAN antibody;Period 1 antibody;Period circadian protein homolog 1 antibody;Period drosophila homolog of antibody;Period homolog 1 antibody;Period1 antibody;RIGUI antibody
SUBCELLULAR LOCATION
Nucleus (By similarity). Cytoplasm (By similarity). Note=Mainly nuclear. Nucleocytoplasmic shuttling is effected by interaction with other circadian core oscillator proteins and/or by phosphorylation. Retention of PER1 in the cytoplasm occurs through PER1-PER2 heterodimer formation or by interaction with CSNK1E and/or phosphorylation which appears to mask the PER1 nuclear localization signal. Also translocated to the nucleus by CRY1 or CRY2 (By similarity).
FUNCTION
This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene may increase the risk of getting certain cancers. Alternative splicing has been observed in this gene; however, these variants have not been fully described.
CITATIONS
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Melatonin-related dysfunction in chronic restraint stress triggers sleep disorders in mice
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WB
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Mouse
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Citation
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