Recombinant Rabbit monoclonal primary
PEN2 Recombinant Rabbit Monoclonal Antibody [JE41-28] (ET7109-26)
Synthetic peptide corresponding to c-terminal human pen2.
Mouse spleen tissue, rat cerebellum tissue, human tonsil tissue, human lung cancer tissue, human kidney tissue, mouse testis tissue, A549, SH-SY-5Y.
Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A purified.
Gamma secretase subunit PEN 2 antibody; Gamma Secretase Subunit PEN2 antibody; Gamma-secretase subunit PEN-2 antibody; Hematopoietic stem/progenitor cells protein MDS033 antibody; MDS033 antibody; MSTP064 antibody; PEN 2 antibody; PEN2_HUMAN antibody; Presenilin Enhancer 2 antibody; Presenilin enhancer 2 homolog antibody; Presenilin enhancer protein 2 antibody; PSEN2 antibody; psenen antibody
Belongs to the PEN-2 family.
Widely expressed. Expressed in leukocytes, lung, placenta, small intestine, liver, kidney, spleen thymus, skeletal muscle, heart and brain.
Cell membrane. Endoplasmic reticulum. Golgi apparatus.
Four proteins comprise the gamma-secretase complex: presenilin, nicastrin, aph-1, and PEN-2. Together, these proteins mediate cell surface signaling pathways for a variety of type I membrane proteins, notably amyloid-beta precursor protein, a protein implicated in the development of Alzheimer's disease, via intramembrane proteolysis. The proteins assemble into a proteolytically active complex in the golgi/trans-golgi network (TGN) compartments. Assembly leads to autocleavage of presenilin into two subunits to create the active site of gamma-secretase, an important step in understanding the mechanisms involved in the etiology and possible treatment of Alzheimer's disease.