PDZK1 Recombinant Rabbit Monoclonal Antibody [JE37-70] (HA722729)

UNIPROT #

Q5T2W1

PROTEIN NAME

PDZK1

SYNONYMS

1700023D20Rik antibody;2610507N21Rik antibody;4921513F16Rik antibody;AI267131 antibody;AI314638 antibody;AL022680 antibody;C terminal linking and modulating protein antibody;CAP70 antibody;CFTR associated protein of 70 kDa antibody;CFTR associated protein, 70-KD antibody;CFTR-associated protein of 70 kDa antibody;CLAMP antibody;D3Ertd537e antibody;Dietary Pi-regulated RNA-1 antibody;Diphor-1 antibody;mPDZK1 antibody;Na(+)/H(+) exchange regulatory cofactor NHE-RF3 antibody;Na(+)/H(+) exchanger regulatory factor 3 antibody;Na/Pi cotransporter C-terminal-associated protein 1 antibody;Na/Pi cotransporter C-terminal-associated protein antibody;NaPi Cap1 antibody;NaPi-Cap1 antibody;NaPiCap1 antibody;NHERF 3 antibody;NHERF-3 antibody;NHERF3 antibody;NHRF3_HUMAN antibody;OTTHUMP00000015572 antibody;PDZ domain containing 1 antibody;PDZ domain containing protein 1 antibody;PDZ domain-containing protein 1 antibody;PDZD1 antibody;PDZK1 antibody;Sodium hydrogen exchanger regulatory factor 3 antibody;Sodium-hydrogen exchanger regulatory factor 3 antibody

SUBCELLULAR LOCATION

Membrane, Cell membrane.

FUNCTION

Na(+)/H(+) exchange regulatory cofactor NHE-RF3 is a protein that in humans is encoded by the PDZK1 gene. This gene encodes a PDZ domain-containing scaffolding protein. PDZ domain-containing molecules bind to and mediate the subcellular localization of target proteins. The encoded protein mediates the localization of cell surface proteins and plays a critical role in cholesterol metabolism by regulating the HDL receptor, scavenger receptor class B type 1. Single nucleotide polymorphisms in this gene may be associated with metabolic syndrome, and overexpression of this gene may play a role in drug resistance of multiple myeloma. Pseudogenes of this gene are located on the long arm of chromosome 1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.