PDX1 Recombinant Rabbit Monoclonal Antibody [JM62-45] (ET1705-99)

UNIPROT #

P52945

PROTEIN NAME

PDX1

SYNONYMS

Glucose sensitive factor antibody;Glucose-sensitive factor antibody;GSF antibody;IDX 1 antibody;IDX-1 antibody;IDX1 antibody;Insulin promoter factor 1 antibody;Insulin promoter factor 1 homeodomain transcription factor antibody;Insulin upstream factor 1 antibody;IPF 1 antibody;IPF-1 antibody;IPF1 antibody;Islet/duodenum homeobox 1 antibody;Islet/duodenum homeobox-1 antibody;IUF 1 antibody;IUF-1 antibody;IUF1 antibody;MODY4 antibody;Pancreas/duodenum homeobox 1 antibody;Pancreas/duodenum homeobox protein 1 antibody;pancreatic and duodenal homeobox P antibody;PDX 1 antibody;PDX-1 antibody;PDX1 antibody;PDX1_HUMAN antibody;Somatostatin transactivating factor 1 antibody;Somatostatin-transactivating factor 1 antibody;STF 1 antibody;STF-1 antibody;STF1 antibody

SEQUENCE SIMILARITIES

Belongs to the Antp homeobox family. IPF1/XlHbox-8 subfamily.

TISSUE SPECIFICITY

Duodenum and pancreas (Langerhans islet beta cells and small subsets of endocrine non-beta-cells, at low levels in acinar cells).

POST-TRANSLATIONAL MODIFICATION

Phosphorylated by the SAPK2 pathway at high intracellular glucose concentration. Phosphorylated by HIPK2 on Ser-268 upon glucose accumulation. This phosphorylation mediates subnuclear localization shifting. Phosphorylation by PASK may lead to translocation into the cytosol (By similarity).

SUBCELLULAR LOCATION

Cytosol, Nucleus.

FUNCTION

Activates insulin, somatostatin, glucokinase, islet amyloid polypeptide and glucose transporter type 2 gene transcription. Particularly involved in glucose-dependent regulation of insulin gene transcription. As part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element. Binds preferentially the DNA motif 5'-[CT]TAAT[TG]-3'. During development, specifies the early pancreatic epithelium, permitting its proliferation, branching and subsequent differentiation. At adult stage, required for maintaining the hormone-producing phenotype of the beta-cell.