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PDX1 Recombinant Rabbit Monoclonal Antibody [JM62-45] (ET1705-99)

Price: Regular price $385.00

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Catalog# ET1705-99

Rabbit Monoclonal to PDX1

Tested for

  • WB

  • IHC-P

  • IF-Cell

  • IF-Tissue

React with

  • Human

Recombinant production enables lot-to-lot consistency and is animal-cruelty-free

Specifications

Product Type

Recombinant Rabbit monoclonal primary

Product Name

PDX1 Recombinant Rabbit Monoclonal Antibody [JM62-45] (ET1705-99)

Immunogen

Synthetic peptide within human pdx1 234-283 / 283.

Host

Rabbit

Positive Control

Hela cell lysates, human pancreas tissue, human gallbladder tissue, human stomach tissue.

Conjugation

Unconjugated

Clonality

Monoclonal

Clone Number

JM62-45

APPLICATION DILUTION

  • WB

  • 1:500-1:1,000

  • IHC-P

  • 1:100-1:800

  • IF-Cell

  • 1:50-1:200

  • IF-Tissue

  • 1:50-1:200

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.

Storage Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1ug/ul

Purification

Protein A affinity purified.

Molecular Weight

Predicted band size: 31 kDa

Isotype

IgG

TARGET

UNIPROT #

P52945

PROTEIN NAME

PDX1

SYNONYMS

Glucose sensitive factor antibody;Glucose-sensitive factor antibody;GSF antibody;IDX 1 antibody;IDX-1 antibody;IDX1 antibody;Insulin promoter factor 1 antibody;Insulin promoter factor 1 homeodomain transcription factor antibody;Insulin upstream factor 1 antibody;IPF 1 antibody;IPF-1 antibody;IPF1 antibody;Islet/duodenum homeobox 1 antibody;Islet/duodenum homeobox-1 antibody;IUF 1 antibody;IUF-1 antibody;IUF1 antibody;MODY4 antibody;Pancreas/duodenum homeobox 1 antibody;Pancreas/duodenum homeobox protein 1 antibody;pancreatic and duodenal homeobox P antibody;PDX 1 antibody;PDX-1 antibody;PDX1 antibody;PDX1_HUMAN antibody;Somatostatin transactivating factor 1 antibody;Somatostatin-transactivating factor 1 antibody;STF 1 antibody;STF-1 antibody;STF1 antibody

SEQUENCE SIMILARITIES

Belongs to the Antp homeobox family. IPF1/XlHbox-8 subfamily.

TISSUE SPECIFICITY

Duodenum and pancreas (Langerhans islet beta cells and small subsets of endocrine non-beta-cells, at low levels in acinar cells).

POST-TRANSLATIONAL MODIFICATION

Phosphorylated by the SAPK2 pathway at high intracellular glucose concentration. Phosphorylated by HIPK2 on Ser-268 upon glucose accumulation. This phosphorylation mediates subnuclear localization shifting. Phosphorylation by PASK may lead to translocation into the cytosol (By similarity).

SUBCELLULAR LOCATION

Cytosol, Nucleus.

FUNCTION

Activates insulin, somatostatin, glucokinase, islet amyloid polypeptide and glucose transporter type 2 gene transcription. Particularly involved in glucose-dependent regulation of insulin gene transcription. As part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element. Binds preferentially the DNA motif 5'-[CT]TAAT[TG]-3'. During development, specifies the early pancreatic epithelium, permitting its proliferation, branching and subsequent differentiation. At adult stage, required for maintaining the hormone-producing phenotype of the beta-cell.

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