PDLIM1 Recombinant Rabbit Monoclonal Antibody [JE55-21] (ET7110-99)

UNIPROT #

O00151

PROTEIN NAME

PDLIM1

SYNONYMS

C terminal LIM domain protein 1 antibody;C-terminal LIM domain protein 1 antibody;Carboxy terminal LIM domain protein 1 antibody;CLIM 1 antibody;CLIM1 antibody;CLP 36 antibody;CLP36 antibody;Elfin antibody;Enigma antibody;Enigma homolog antibody;hCLIM 1 antibody;hCLIM1 antibody;LIM domain protein CLP 36 antibody;LIM domain protein CLP-36 antibody;LIM domain protein CLP36 antibody;PDLI1_HUMAN antibody;PDLIM 1 antibody;Pdlim1 antibody;PDZ and LIM domain 1 antibody;PDZ and LIM domain protein 1 antibody

TISSUE SPECIFICITY

Strongly expressed in the heart and skeletal muscle, moderately expressed in the spleen, small intestine, colon, placenta, and lung. A lower level expression is seen in liver, thymus, kidney, prostate and pancreas and is not found in the brain, testis, ovary, and peripheral blood leukocytes.

SUBCELLULAR LOCATION

Cytoskeleton, cytoplasm, Z line.

FUNCTION

PDLIM1, also known as CLP36, CLIM1 or Elfin, is a 329 amino acid cytoplasmic protein that associates with Actin stress fibers at the cytoskeleton. Expressed at high levels in skeletal muscle and heart and at lower levels in colon, small intestine, spleen, lung, placenta, kidney, liver, thymus and pancreas, CLP36 functions as a cytoskeletal protein that is thought to act as an adaptor, bringing target proteins to the cytoskeleton. Specifically, CLP36 interacts with Clik1 (a kinase) and recruits Clik1 to α-actinin-1, thereby facilitating the association of Clik1 with Actin stress fibers. CLP36 contains one PDZ domain and one LIM zinc-binding domain through which it conveys its protein-protein binding capabilities. Human CLP36 shares 88% sequence similarity with its rat counterpart, suggesting a conserved function between species.