PDK2 Recombinant Rabbit Monoclonal Antibody [JB66-93] (ET7107-46)

UNIPROT #

Q15119

PROTEIN NAME

PDK2

SYNONYMS

[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2 antibody;mitochondrial antibody;PDHK2 antibody;PDK2 antibody;PDK2_HUMAN antibody;Pyruvate dehydrogenase kinase isoform 2 antibody;Pyruvate dehydrogenase kinase, isozyme 2 antibody;Pyruvate dehydrogenase lipoamide kinase isozyme 2, mitochondrial antibody

SEQUENCE SIMILARITIES

Belongs to the PDK/BCKDK protein kinase family.

TISSUE SPECIFICITY

Expressed in many tissues, with the highest level in heart and skeletal muscle, intermediate levels in brain, kidney, pancreas and liver, and low levels in placenta and lung.

SUBCELLULAR LOCATION

Mitochondrion.

FUNCTION

Pyruvate dehydrogenase kinase isoform 2 (PDK2) also known as pyruvate dehydrogenase lipoamide kinase isozyme 2, mitochondrial is an enzyme that in humans is encoded by the PDK2 gene. PDK2 is an isozyme of pyruvate dehydrogenase kinase. The Pyruvate Dehydrogenase (PDH) complex must be tightly regulated due to its central role in general metabolism. Within the complex, there are three serine residues on the E1 component that are sites for phosphorylation; this phosphorylation inactivates the complex. In humans, there have been four isozymes of Pyruvate Dehydrogenase Kinase that have been shown to phosphorylate these three sites: PDK1, PDK2, PDK3, and PDK4. PDK2 has been identified as the most abundant isoform in human tissues. Through many studies, it has been made clear that the activity of this enzyme is essential, even at rest, to regulate glycolysis/carbodydrate oxidation and producing metabolites for oxidative phosphorylation and the electron transport chain. These studies have illustrated that the kinetics of the PDK isoform population, specifically PDK2, is more important in determining PDH activity than measuring PDK activity.