PDI Rabbit Polyclonal Antibody (ER40404)
Catalog# ER40404
Rabbit Polyclonal to PDI
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WB
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ICC
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IHC-P
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Human
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Mouse
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Rat
Positive control:
Lane 1: Hela Lane 2: MCF-7
Lane 3: PANC Lane 4: HepG2
Lane 5: HUVEC Lane 6: NIH/3T3
Lane 7: L929 Lane 8: F9
Lane 9: Jurkat Lane 10: A431
Lane 11: A549 Lane 12: Mouse liver
Lane 13: Mouse kidney Lane 14: Mouse brain
Lane 15: Human kidney Lane 16: Human brain
Lane 17: Human liver
Specifications
Product Type
Rabbit polyclonal primary
Product Name
PDI Rabbit Polyclonal Antibody (ER40404)
Immunogen
Synthetic peptide within residues of pdi aa 476-525 / 525.
Host
Rabbit
Positive Control
Hela, MCF-7, PANC,HepG2, HUVEC, NIH/3T3, L929, F9, Jurkat, A431, A549, mouse liver tissue, mouse kidney tissue, mouse brain tissue,human lung carcinoma tissue，human kidney,Human brain,Human liver,human colon carcinoma tissue.
Conjugation
Unconjugated
Clonality
Polyclonal
APPLICATION DILUTION
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WB
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1:500-1:1,000
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ICC
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1:200
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IHC-P
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1:200
PROPERTIES
Form
Liquid
Storage Condition
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
Storage Buffer
1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1ug/ul
Purification
Immunogen affinity purified.
Molecular Weight
58 kDa
Isotype
IgG
TARGET
UNIPROT #
PROTEIN NAME
PDI
SYNONYMS
Pancreas specific protein disulfide isomerase antibody;Pancreas-specific protein disulfide isomerase antibody;Pancreatic protein disulfide isomerase antibody;PDA2 antibody;PDI antibody;PDIA2 antibody;PDIA2_HUMAN antibody;PDIp antibody;PDIR antibody;Protein disulfide isomerase A2 antibody;Protein disulfide isomerase antibody;Protein disulfide isomerase associated 2 antibody;Protein disulfide isomerase family A member 2 antibody;Protein disulfide isomerase pancreatic antibody;Protein disulfide-isomerase A2 antibody;Rho GDP dissociation inhibitor gamma antibody
SEQUENCE SIMILARITIES
Belongs to the protein disulfide isomerase family.
TISSUE SPECIFICITY
Highly expressed in pancreas (at protein level).
POST-TRANSLATIONAL MODIFICATION
The disulfide-linked homodimer exhibits an enhanced chaperone activity.; Glycosylated.
SUBCELLULAR LOCATION
Endoplasmic reticulum lumen
FUNCTION
Protein disulfide isomerase or PDI is an enzyme in the endoplasmic reticulum in eukaryotes that catalyzes the formation and breakage of disulfide bonds between cysteine residues within proteins as they fold. Another major function of PDI relates to its activity as a chaperone; i.e., it aids wrongly folded proteins to reach a correctly folded state without the aid of enzymatic disulfide shuffling. PDI has been found to be involved in the breaking of bonds on the HIV gp120 protein during HIV infection of CD4 positive cells, and is required for HIV infection of lymphocytes and monocytes.
CITATIONS
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Cao, X., Shu, Y., Chen, Y., Xu, Q., Guo, G., Wu...
Mettl14-Mediated m6A Modification Facilitates Liver Regeneration by Maintaining Endoplasmic Reticulum Homeostasis. Cellular and molecular gastroenterology and hepatology, S2352-345X(21)00072-2. Advance online publication.
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WB
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Mouse
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Citation
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