PDI Rabbit Polyclonal Antibody (ER40404)
Catalog# ER40404
Rabbit Polyclonal to PDI
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WB
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IF-Cell
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IHC-P
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Human
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Mouse
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Rat
Positive control:
Lane 1: Hela cell lysate
Lane 2: MCF-7 cell lysate
Lane 3: PANC cell lysate
Lane 4: HepG2 cell lysate
Lane 5: HUVEC cell lysate
Lane 6: NIH/3T3 cell lysate
Lane 7: L929 cell lysate
Lane 8: F9 cell lysate
Lane 9: Jurkat cell lysate
Lane 10: A431 cell lysate
Lane 11: A549 cell lysate
Lane 12: Mouse liver tissue lysate
Lane 13: Mouse kidney tissue lysate
Lane 14: Mouse brain tissue lysate
Lane 15: Human kidney tissue lysate
Lane 16: Human brain tissue lysate
Lane 17: Human liver tissue lysate
Specifications
Product Type
Rabbit polyclonal primary
Product Name
PDI Rabbit Polyclonal Antibody (ER40404)
Immunogen
Synthetic peptide within residues of pdi aa 476-525 / 525.
Host
Rabbit
Positive Control
Hela cell lysate, MCF-7 cell lysate, PANC cell lysate, HepG2 cell lysate, HUVEC cell lysate, NIH/3T3 cell lysate, L929 cell lysate, F9 cell lysate, Jurkat cell lysate, A431 cell lysate, A549 cell lysate, mouse liver tissue lysate, mouse kidney tissue lysate, mouse brain tissue lysate, Human kidney tissue lysate, Human brain tissue lysate, Human liver tissue lysate, HUVEC, A549, NIH/3T3, human lung carcinoma tissue, human colon carcinoma tissue.
Conjugation
Unconjugated
Clonality
Polyclonal
RRID
APPLICATION DILUTION
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WB
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1:500-1:1,000
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IF-Cell
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1:200
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IHC-P
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1:200
PROPERTIES
Form
Liquid
Storage Condition
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
Storage Buffer
1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1ug/ul
Purification
Immunogen affinity purified.
Molecular Weight
Predicted band size: 58 kDa
Isotype
IgG
TARGET
UNIPROT #
PROTEIN NAME
PDI
SYNONYMS
Pancreas specific protein disulfide isomerase antibody;Pancreas-specific protein disulfide isomerase antibody;Pancreatic protein disulfide isomerase antibody;PDA2 antibody;PDI antibody;PDIA2 antibody;PDIA2_HUMAN antibody;PDIp antibody;PDIR antibody;Protein disulfide isomerase A2 antibody;Protein disulfide isomerase antibody;Protein disulfide isomerase associated 2 antibody;Protein disulfide isomerase family A member 2 antibody;Protein disulfide isomerase pancreatic antibody;Protein disulfide-isomerase A2 antibody;Rho GDP dissociation inhibitor gamma antibody
SEQUENCE SIMILARITIES
Belongs to the protein disulfide isomerase family.
TISSUE SPECIFICITY
Highly expressed in pancreas (at protein level).
POST-TRANSLATIONAL MODIFICATION
The disulfide-linked homodimer exhibits an enhanced chaperone activity.; Glycosylated.
SUBCELLULAR LOCATION
Endoplasmic reticulum.
FUNCTION
Protein disulfide isomerase or PDI is an enzyme in the endoplasmic reticulum in eukaryotes that catalyzes the formation and breakage of disulfide bonds between cysteine residues within proteins as they fold. Another major function of PDI relates to its activity as a chaperone; i.e., it aids wrongly folded proteins to reach a correctly folded state without the aid of enzymatic disulfide shuffling. PDI has been found to be involved in the breaking of bonds on the HIV gp120 protein during HIV infection of CD4 positive cells, and is required for HIV infection of lymphocytes and monocytes.
CITATIONS
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Copper induce zebrafish retinal developmental defects via triggering stresses and apoptosis
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IF
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zebrafish
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Citation
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Cao, X., Shu, Y., Chen, Y., Xu, Q., Guo, G., Wu, Z., Shao, M., Zhou, Y., Chen, M., Gong, Y., Li, C., Shi, Y., & Bu, H.
Mettl14-Mediated m6A Modification Facilitates Liver Regeneration by Maintaining Endoplasmic Reticulum Homeostasis. Cellular and molecular gastroenterology and hepatology, S2352-345X(21)00072-2. Advance online publication.
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WB
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Mouse
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Citation
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