PDIA2 Recombinant Rabbit Monoclonal Antibody [JF97-08] (ET1702-70)

UNIPROT #

Q13087

PROTEIN NAME

PDIA2

SYNONYMS

Pancreas specific protein disulfide isomerase antibody;Pancreas-specific protein disulfide isomerase antibody;Pancreatic protein disulfide isomerase antibody;PDA2 antibody;PDI antibody;PDIA2 antibody;PDIA2_HUMAN antibody;PDIp antibody;PDIR antibody;Protein disulfide isomerase A2 antibody;Protein disulfide isomerase antibody;Protein disulfide isomerase associated 2 antibody;Protein disulfide isomerase family A member 2 antibody;Protein disulfide isomerase pancreatic antibody;Protein disulfide-isomerase A2 antibody;Rho GDP dissociation inhibitor gamma antibody

SEQUENCE SIMILARITIES

Belongs to the protein disulfide isomerase family.

SUBCELLULAR LOCATION

Endoplasmic reticulum, Endoplasmic reticulum lumen, Melanosome, Cell membrane.

FUNCTION

Oxidoreductase-protein disulfide isomerase (PDI) is a homodimer consisting of subunits that catalyzes thiol-disulfide exchange, mediates folding of newly synthesized proteins and functions as a molecular chaperone. PDI localizes to the lumen of the endoplasmic reticulum (ER), where in conjunction with folding-helper proteins, such as immunoglobulin heavy chain binding protein (BiP), mediates tertiary and quaternary protein-processing. Cell surface PDI induces sulfhydryl-mediated conformational changes in integrin-mediated adhesion receptor-ligand interactions, thereby regulating integrin responses and cell adhesion. Additionally, PDI functions as a subunit of two more complex enzyme systems: the prolyl-4-hydroxylase and the triacylglycerol transfer proteins.