Lane 1: NIH/3T3
Lane 2: Human liver
Recombinant Rabbit monoclonal primary
PDI Recombinant Rabbit Monoclonal Antibody [JF97-08] (ET1702-70)
NIH/3T3, human liver tissue.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A purified.
Pancreas specific protein disulfide isomerase antibody; Pancreas-specific protein disulfide isomerase antibody; Pancreatic protein disulfide isomerase antibody; PDA2 antibody; PDI antibody; PDIA2 antibody; PDIA2_HUMAN antibody; PDIp antibody; PDIR antibody; Protein disulfide isomerase A2 antibody; Protein disulfide isomerase antibody; Protein disulfide isomerase associated 2 antibody; Protein disulfide isomerase family A member 2 antibody; Protein disulfide isomerase pancreatic antibody; Protein disulfide-isomerase A2 antibody; Rho GDP dissociation inhibitor gamma antibody
Belongs to the protein disulfide isomerase family.
Endoplasmic reticulum, Endoplasmic reticulum lumen, Melanosome, Cell membrane.
Oxidoreductase-protein disulfide isomerase (PDI) is a homodimer consisting of subunits that catalyzes thiol-disulfide exchange, mediates folding of newly synthesized proteins and functions as a molecular chaperone. PDI localizes to the lumen of the endoplasmic reticulum (ER), where in conjunction with folding-helper proteins, such as immunoglobulin heavy chain binding protein (BiP), mediates tertiary and quaternary protein-processing. Cell surface PDI induces sulfhydryl-mediated conformational changes in integrin-mediated adhesion receptor-ligand interactions, thereby regulating integrin responses and cell adhesion. Additionally, PDI functions as a subunit of two more complex enzyme systems: the prolyl-4-hydroxylase and the triacylglycerol transfer proteins.