PDE10A Recombinant Rabbit Monoclonal Antibody [PSH03-61] (HA722020)

UNIPROT #

Q9Y233

PROTEIN NAME

PDE10A

SYNONYMS

5''-cyclic phosphodiesterase 10A antibody;cAMP and cAMP inhibited cGMP 3'5' cyclic phosphodiesterase 10A antibody;cAMP and cAMP-inhibited cGMP 3'' antibody;FLJ11894 antibody;HSPDE 10A antibody;HSPDE10A antibody;PDE 10A antibody;PDE10_HUMAN antibody;Pde10a antibody;Phosphodiesterase 10A antibody;Phosphodiesterase 10A1 antibody

SUBCELLULAR LOCATION

Cytoplasm, cytosol.

FUNCTION

The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase family. It plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This protein can hydrolyze both cAMP and cGMP to the corresponding nucleoside 5' monophosphate, but has higher affinity for cAMP, and is more efficient with cAMP as substrate. Alternatively spliced transcript variants have been described for this gene. Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate. May play a critical role in regulating cAMP and cGMP levels in the striatum, a region of the brain that contributes to the control of movement and cognition.