PCNA Recombinant Mouse Monoclonal Antibody [A6-G11-R] (HA601172)

UNIPROT #

P12004

PROTEIN NAME

PCNA

SYNONYMS

ATLD2 antibody;cb16 antibody;Cyclin antibody;DNA polymerase delta auxiliary protein antibody;etID36690.10 antibody;fa28e03 antibody;fb36g03 antibody;HGCN8729 antibody;MGC8367 antibody;Mutagen-sensitive 209 protein antibody;OTTHUMP00000030189 antibody;OTTHUMP00000030190 antibody;PCNA antibody;Pcna/cyclin antibody;PCNA_HUMAN antibody;PCNAR antibody;Polymerase delta accessory protein antibody;Proliferating cell nuclear antigen antibody;wu:fa28e03 antibody;wu:fb36g05 antibody

SUBCELLULAR LOCATION

Nucleus

FUNCTION

Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'-phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA repair and DNA damage tolerance pathways. Acts as a loading platform to recruit DDR proteins that allow completion of DNA replication after DNA damage and promote postreplication repair: Monoubiquitinated PCNA leads to recruitment of translesion (TLS) polymerases, while 'Lys-63'-linked polyubiquitination of PCNA is involved in error-free pathway and employs recombination mechanisms to synthesize across the lesion.