PCBP1 Mouse Monoclonal Antibody [A3E10] (HA600019)

UNIPROT #

Q15365

PROTEIN NAME

PCBP1

SYNONYMS

Alpha-CP1 antibody;Heterogeneous nuclear ribonucleoprotein E1 antibody;heterogenous nuclear ribonucleoprotein E1 antibody;heterogenous nuclear ribonucleoprotein X antibody;hnRNP E1 antibody;hnRNP-E1 antibody;hnRNP-X antibody;HNRPE1 antibody;HNRPX antibody;nucleic acid binding protein sub 2.3 antibody;Nucleic acid- binding protein SUB2.3 antibody;Nucleic acid-binding protein SUB2.3 antibody;PCBP1 antibody;PCBP1_HUMAN antibody;poly(rC) binding protein 1 antibody;Poly(rC)-binding protein 1 antibody;rCbinding protein 1 antibody

SUBCELLULAR LOCATION

Cytoplasm, Nucleus.

FUNCTION

This intronless gene is thought to have been generated by retrotransposition of a fully processed PCBP-2 mRNA. This gene and PCBP-2 have paralogues (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. The protein encoded by this gene appears to be multifunctional. It along with PCBP2 and HNRNPK corresponds to the major cellular poly(rC)-binding protein. It contains three K-homologous (KH) domains which may be involved in RNA binding. This encoded protein together with PCBP-2 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure.