PBX1 Rabbit Polyclonal Antibody (ER1914-79)

UNIPROT #

P40424

PROTEIN NAME

PBX1

SYNONYMS

DKFZp686B09108 antibody;Homeo box protein PBX1 antibody;Homeo box protein PRL antibody;Homeobox protein PBX 1 antibody;Homeobox protein PBX1 antibody;Homeobox protein PRL antibody;MGC126627 antibody;PBX 1 antibody;Pbx1 antibody;PBX1_HUMAN antibody;Pre B cell leukemia homeobox 1 antibody;Pre B cell leukemia transcription factor 1 antibody;Pre-B-cell leukemia transcription factor 1 antibody;PRL antibody

SUBCELLULAR LOCATION

Nucleus.

FUNCTION

This gene encodes a nuclear protein that belongs to the PBX homeobox family of transcriptional factors. Studies in mice suggest that this gene may be involved in the regulation of osteogenesis and required for skeletal patterning and programming. A chromosomal translocation, t(1;19) involving this gene and TCF3/E2A gene, is associated with pre-B-cell acute lymphoblastic leukemia. The resulting fusion protein, in which the DNA binding domain of E2A is replaced by the DNA binding domain of this protein, transforms cells by constitutively activating transcription of genes regulated by the PBX protein family. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.