PRODUCT CODE: ER1802-11

PBR Rabbit Polyclonal Antibody (ER1802-11)

Applications

  • WB

  • IHC-P

REACTIVITY

  • Human

  • Mouse

Western blot analysis of PBR on A431 and PC-3M cell lysateS using anti-PBR antibody at 1/500 dilution.
  • Western blot analysis of PBR on A431 and PC-3M cell lysateS using anti-PBR antibody at 1/500 dilution.
  • Immunohistochemical analysis of paraffin-embedded human kidney tissue using anti-PBR antibody. Counter stained with hematoxylin.
  • Immunohistochemical analysis of paraffin-embedded mouse colon tissue using anti-PBR antibody. Counter stained with hematoxylin.
  • Immunohistochemical analysis of paraffin-embedded mouse brain tissue using anti-PBR antibody. Counter stained with hematoxylin.
  • Immunohistochemical analysis of paraffin-embedded human colon cancer tissue using anti-PBR antibody. Counter stained with hematoxylin.
Western blot analysis of PBR on A431 and PC-3M cell lysateS using anti-PBR antibody at 1/500 dilution.

Applications

  • WB

  • IHC-P

REACTIVITY

  • Human

  • Mouse

SPECIFICATIONS

Product Type

Rabbit polyclonal primary

Product Name

PBR Rabbit Polyclonal Antibody (ER1802-11)

Immunogen

Recombinant protein within human pbr aa 1-183 / 169.

Host

Rabbit

Positive Control

A431, PC-3M, human colon cancer tissue, human kidney tissue, mouse colon tissue, mouse brain tissue.

Conjugation

Unconjugated

Clonality

Polyclonal

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.

Storage Buffer

1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1 ug/ul

PURIFICATION

Protein affinity purified

MOLECULAR WEIGHT

10/18 kDa

Isotype

IgG

APPLICATION DILUTION

  • WB

  • 1:500-1:2,000

  • IHC-P

  • 1:50-1:200

TARGET

UNIPROT #

PROTEIN NAME

PBR

SYNONYMS

Benzodiazapine receptor (peripheral) antibody; Benzodiazepine peripheral binding site antibody; BPBS antibody; BZRP antibody; DBI antibody; IBP antibody; Isoquinoline carboxamide-binding protein antibody; MBR antibody; mDRC antibody; Mitochondrial benzodiazepine receptor antibody; PBR antibody; PBS antibody; Peripheral benzodiazepine receptor antibody; Peripheral benzodiazepine receptor-related protein antibody; Peripheral type benzodiazepine receptor antibody; Peripheral-type benzodiazepine receptor antibody; pk18 antibody; PKBS antibody; PTBR antibody; Ptbzr antibody; PTBZR02 antibody; RATPTBZR02 antibody; translocator protein (18kDa) antibody; Translocator protein antibody; Tspo antibody; Tspo1 antibody; TSPOA_HUMAN antibody

SEQUENCE SIMILARITIES

Belongs to the TspO/BZRP family.

TISSUE SPECIFICITY

Found in many tissue types. Expressed at the highest levels under normal conditions in tissues that synthesize steroids.

SUBCELLULAR LOCATION

Mitochondrion.

FUNCTION

Present mainly in the mitochondrial compartment of peripheral tissues, the protein encoded by this gene interacts with some benzodiazepines and has different affinities than its endogenous counterpart. Can bind protoporphyrin IX and may play a role in the transport of porphyrins and heme. Promotes the transport of cholesterol across mitochondrial membranes and may play a role in lipid metabolism, but its precise physiological role is controversial. It is apparently not required for steroid hormone biosynthesis. Was initially identified as peripheral-type benzodiazepine receptor; can also bind isoquinoline carboxamides. Alternatively spliced transcript variants have been reported; one of the variants lacks an internal exon and is considered non-coding, and the other variants encode the same protein.