Recombinant Rabbit monoclonal primary
PAX8 Recombinant Rabbit Monoclonal Antibody [JJ08-88] (ET1701-50)
Recombinant protein within human pax8 aa 101-450 / 450.
SKOV-3 cell lysates, SKOV-3, human thyroid tissue, human ovarian carcinoma tissue, human thyroid cancer tissue, human kidney tissue.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A affinity purified.
OTTHUMP00000158659 antibody;OTTHUMP00000158660 antibody;OTTHUMP00000203723 antibody;OTTHUMP00000203724 antibody;Paired box 8 antibody;Paired box gene 8 antibody;paired box homeotic gene 8 antibody;Paired box protein Pax 8 antibody;Paired box protein Pax-8 antibody;Paired domain gene 8 antibody;PAX 8 antibody;PAX8 antibody;PAX8_HUMAN antibody
Expressed in the excretory system, thyroid gland and Wilms tumors.
In developing excretory system, during thyroid differentiation and in adult thyroid.
PAX8 is a transcription factor crucial to the organogenesis and development of the thyroid gland, urogenital tract, placenta and inner ear. In the thyroid, PAX8 is a master gene that regulates maintenance of the differentiated thyroid follicular cell phenotype, where it controls and activates the transcription of the main proteins responsible for the functional activity of follicular cells such as thyroglobulin, thyroperoxidase and sodium/iodide symporter. In the developing kidney PAX8 is important for renal vescicle formation. PAX8 regulates the expression of the WT1 gene. PAX8 appears to be currently the most sensitive and specific marker for renal cell carcinoma and ovarian non-mucinous carcinoma. Follicular and papillary thyroid carcinoma are virually always PAX8 positive (while anaplastic carcinoma is positive in most cases and medullary thyroid carcinoma negative). PAX8 is also found in almost all cases of ovarian serous, endometrioid, transitional and clear cell carcinoma (while mucinous carcinoma is positive in a minor number of cases), and endometrial carcinoma.