PAX8 Mouse Monoclonal Antibody [6G5] (EM1701-81)

UNIPROT #

Q06710

PROTEIN NAME

PAX8

SYNONYMS

OTTHUMP00000158659 antibody;OTTHUMP00000158660 antibody;OTTHUMP00000203723 antibody;OTTHUMP00000203724 antibody;Paired box 8 antibody;Paired box gene 8 antibody;paired box homeotic gene 8 antibody;Paired box protein Pax 8 antibody;Paired box protein Pax-8 antibody;Paired domain gene 8 antibody;PAX 8 antibody;PAX8 antibody;PAX8_HUMAN antibody

TISSUE SPECIFICITY

Expressed in the excretory system, thyroid gland and Wilms tumors.

DEVELOPMENTAL STAGE

In developing excretory system, during thyroid differentiation and in adult thyroid.

SUBCELLULAR LOCATION

Nucleus.

FUNCTION

The PAX gene family has an important role in the formation of tissues and organs during embryonic development and maintaining the normal function of some cells after birth. The PAX genes give instructions for making proteins that attach themselves to certain areas of DNA. This nuclear protein is involved in thyroid follicular cell development and expression of thyroid-specific genes. PAX8 releases the hormones important for regulating growth, brain development, and metabolism. Also functions in very early stages of kidney organogenesis, the müllerian system, and the thymus. Additionally, PAX8 is expressed in the renal excretory system, epithelial cells of the endocervix, endometrium, ovary, Fallopian tube, seminal vesicle, epididymis, pancreatic islet cells and lymphoid cells. PAX8 and other transcription factors play a role in binding to DNA and regulating the genes that drive thyroid hormone synthesis (Tg, TPO, Slc5a5 and Tshr). This PAX-8 antibody is intended for qualified laboratories to qualitatively identify by light microscopy the presence of associated antigens in sections of formalinfixed, paraffin-embedded tissue sections using IHC test methods.