Recombinant Rabbit monoclonal primary
PAX5 Recombinant Rabbit Monoclonal Antibody [JJ08-87] (ET1701-49)
Daudi cell lysates, Hela, MCF-7, HepG2, human spleen tissue, human tonsil tissue, Raji.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A affinity purified.
B cell lineage specific activator antibody; B cell lineage specific activator protein antibody; B cell specific activator protein antibody; B cell specific transcription factor antibody; B-cell-specific transcription factor antibody; BSAP antibody; EBB-1 antibody; KLP antibody; Paired box 5 antibody; Paired box gene 5 (B cell lineage specific activator protein) antibody; Paired box gene 5 (B cell lineage specific activator) antibody; Paired box gene 5 antibody; Paired box homeotic gene 5 antibody; Paired box protein Pax 5 antibody; Paired box protein Pax-5 antibody; Paired domain gene 5 antibody; PAX 5 antibody; PAX5 antibody; PAX5_HUMAN antibody; Transcription factor PAX 5 antibody
Expressed at early B-cell differentiation, in the developing CNS and in adult testis.
The Pax family of nuclear transcription factors is comprised of nine members that function during embryogenesis to regulate the temporal and position-dependent differentiation of cells. Pax family genes are also involved in a variety of signal transduction pathways in the adult organism. Mutations in Pax proteins have been linked to disease and cancer in humans. For example, the human PAX5 gene encodes a B cell lineage-specific protein, Pax-5, also designated B cell specific activator protein or BSAP, which is expressed in pro-B, pre-B and mature B lymphocytes but not in plasma cells. Pax-5 functions to regulate not only B cell development, but also influences the balance between immunoglobulin secretion and B cell proliferation. Overexpression of Pax-5 has been implicated in cellular transformation, and in the case of small lymphocytic lymphomas with plasmacytoid differentiation, a t(9;14)(p13;q32) translocation resulting in the deregulation of PAX5 gene expression has been detected.