PAS2 Rabbit Polyclonal Antibody (ER1902-29)

UNIPROT #

Q8VZB2

PROTEIN NAME

PAS2

SYNONYMS

Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase PASTICCINO 2Curated;3-hydroxyacyl-CoA dehydratase PASTICCINO 2;AtPAS2;HACD;HCD;Protein PEPINO;Protein tyrosine phosphatase-like protein;PAS2;PEP;At5g10480;F12B17.170

SEQUENCE SIMILARITIES

Belongs to the very long-chain fatty acids dehydratase HACD family.

TISSUE SPECIFICITY

High expression in young seedlings, roots, root tips, flowers and young siliques. Lower levels in leaves and stems.

SUBCELLULAR LOCATION

Nucleus, endoplasmic reticulum membrane, cytoplasm.

FUNCTION

Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May be an anti-phosphatase that prevents CDKA-1 dephosphorylation and activation. Involved in the hormonal control of cell division and differentiation. Required for proliferation control of meristematic and non-meristematic cells. Negative regulator of the cell cycle.