PARP2 Recombinant Rabbit Monoclonal Antibody [JG34-56] (ET7108-05)

UNIPROT #

Q9UGN5

PROTEIN NAME

PARP2

SYNONYMS

ADP ribosyltransferase like 2 antibody;ADP-ribosyltransferase diphtheria toxin-like 2 antibody;ADPRT 2 antibody;ADPRT-2 antibody;ADPRT2 antibody;ADPRTL 2 antibody;ADPRTL 3 antibody;ADPRTL2 antibody;ADPRTL3 antibody;ARTD2 antibody;hPARP 2 antibody;hPARP-2 antibody;hPARP2 antibody;NAD(+) ADP ribosyltransferase 2 antibody;NAD(+) ADP-ribosyltransferase 2 antibody;pADPRT 2 antibody;pADPRT-2 antibody;pADPRT2 antibody;PARP 2 antibody;PARP-2 antibody;PARP2 antibody;PARP2_HUMAN antibody;Poly (ADP ribose) polymerase family member 2 antibody;Poly (ADP ribosyl) transferase like 2 antibody;poly (ADP-ribose) polymerase 2 antibody;Poly [ADP ribose] synthetase 2 antibody;Poly [ADP-ribose] polymerase 2 antibody;Poly(ADP ribose) synthetase antibody;Poly[ADP-ribose] synthase 2 antibody

TISSUE SPECIFICITY

Widely expressed, mainly in actively dividing tissues. The highest levels are in the brain, heart, pancreas, skeletal muscle and testis; also detected in kidney, liver, lung, placenta, ovary and spleen; levels are low in leukocytes, colon, small intestine, prostate and thymus.

POST-TRANSLATIONAL MODIFICATION

Poly-ADP-ribosylated by PARP1.; Acetylation reduces DNA binding and enzymatic activity.

SUBCELLULAR LOCATION

Chromosome, Nucleus.

FUNCTION

Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. Mediates serine ADP-ribosylation of target proteins following interaction with HPF1; HPF1 conferring serine specificity.