Applications
-
WB
-
IHC-P
-
ICC
REACTIVITY
-
Human
-
Mouse
-
Rat
SPECIFICATIONS
Product Type
Rabbit polyclonal primary
Product Name
Pannexin 2 Rabbit Polyclonal Antibody (ER1901-05)
Immunogen
Synthetic peptide within human pannexin 2 71-95.
Host
Rabbit
Positive Control
HepG2.
Conjugation
Unconjugated
Clonality
Polyclonal
PROPERTIES
Form
Liquid
Storage Condition
Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.
Storage Buffer
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1 ug/ul
PURIFICATION
Peptide affinity purified.
MOLECULAR WEIGHT
74 kDa
Isotype
IgG
APPLICATION DILUTION
-
WB:1:500-1:2,000
-
ICC:1:50-1:200
-
IHC-P:1:100-1:400
TARGET
UNIPROT #
PROTEIN NAME
Pannexin 2
SYNONYMS
hPANX2 antibody; Pannexin 2 antibody; Pannexin-2 antibody; PANX 2 antibody; Panx2 antibody; PANX2_HUMAN antibody; Px2 antibody
SEQUENCE SIMILARITIES
Belongs to the pannexin family.
SUBCELLULAR LOCATION
Cell membrane. Gap junction.
FUNCTION
The protein encoded by this gene belongs to the innexin family. Innexin family members are the structural components of gap junctions. This protein and pannexin 1 are abundantly expressed in central nervous system (CNS) and are coexpressed in various neuronal populations. Studies in Xenopus oocytes suggest that this protein alone and in combination with pannexin 1 may form cell type-specific gap junctions with distinct properties. Multiple transcript variants encoding different isoforms have been found for this gene. Structural component of the gap junctions and the hemichannels. Pannexin 2 is an important regulator of the insulin secretory capacity and apoptosis in pancreatic β-cells.