Pannexin 2 Rabbit Polyclonal Antibody (ER1901-05)

UNIPROT #

Q96RD6

PROTEIN NAME

Pannexin 2

SYNONYMS

hPANX2 antibody;Pannexin 2 antibody;Pannexin-2 antibody;PANX 2 antibody;Panx2 antibody;PANX2_HUMAN antibody;Px2 antibody

SEQUENCE SIMILARITIES

Belongs to the pannexin family.

SUBCELLULAR LOCATION

Cell membrane. Gap junction.

FUNCTION

The protein encoded by this gene belongs to the innexin family. Innexin family members are the structural components of gap junctions. This protein and pannexin 1 are abundantly expressed in central nervous system (CNS) and are coexpressed in various neuronal populations. Studies in Xenopus oocytes suggest that this protein alone and in combination with pannexin 1 may form cell type-specific gap junctions with distinct properties. Multiple transcript variants encoding different isoforms have been found for this gene. Structural component of the gap junctions and the hemichannels. Pannexin 2 is an important regulator of the insulin secretory capacity and apoptosis in pancreatic β-cells.