p95 NBS1 Recombinant Rabbit Monoclonal Antibody [SC05-68] (ET1610-26)

UNIPROT #

O60934

PROTEIN NAME

p95 NBS1

SYNONYMS

AT V1 antibody;AT V2 antibody;ATV antibody;Cell cycle regulatory protein p95 antibody;FLJ10155 antibody;MGC87362 antibody;Nbn antibody;NBN_HUMAN antibody;NBS 1 antibody;NBS antibody;NBS1 antibody;Nibrin antibody;Nijmegen breakage syndrome 1 (nibrin) antibody;Nijmegen breakage syndrome antibody;Nijmegen breakage syndrome protein 1 antibody;p95 antibody;p95 protein of the MRE11/RAD50 complex antibody

TISSUE SPECIFICITY

Ubiquitous. Expressed at high levels in testis.

POST-TRANSLATIONAL MODIFICATION

Phosphorylated by ATM in response of ionizing radiation, and such phosphorylation is responsible intra-S phase checkpoint control and telomere maintenance.

SUBCELLULAR LOCATION

Nucleus, Chromosome.

FUNCTION

DNA repair proteins are necessary for the maintenance of chromosome integrity and are involved in the elimination of premutagenic lesions from DNA. The DNA repair proteins Rad51 and Rad52 are key components of the double-strand-break repair (DSBR) pathway. Rad51 is essential for mitotic and meiotic recombination, and its mutation in yeast and mammalian cells results in chromosome loss. Overexpression of Rad52 confers resistance to ionizing radiation and induces homologous intrachromosomal recombination. Rad52 is thought to be involved in an early stage of Rad51-mediated recombination. Additional proteins involved in the pathway include Dmc1 and nibrin. Dmc1 is specifically involved in meiotic recombination. Nibrin, which complexes with Mre11 and Rad50, is absent in Nijemegen breakage syndrome (NBS) patients.