p75 NGF Receptor Recombinant Rat Monoclonal Antibody [PSH13-26] (HA601436)

UNIPROT #

Q9Z0W1

PROTEIN NAME

p75 NGF Receptor

SYNONYMS

CD271 antibody;CD271 antigen antibody;Gp80 LNGFR antibody;Gp80-LNGFR antibody;Low affinity nerve growth factor receptor antibody;Low affinity neurotrophin receptor p75NTR antibody;Low-affinity nerve growth factor receptor antibody;Nerve growth factor receptor antibody;Nerve growth factor receptor TNFR superfamily member 16 antibody;NGF receptor antibody;Ngfr antibody;p75 ICD antibody;p75 Neurotrophin receptor antibody;p75 NTR antibody;p75(NTR) antibody;p75NTR antibody;TNFR Superfamily Member 16 antibody;TNFRSF16 antibody;TNR16_HUMAN antibody;Tumor necrosis factor receptor superfamily member 16 antibody

SUBCELLULAR LOCATION

Cell membrane, Cytoplasm, Perikaryon, Cell projection, growth cone, dendritic spine.

FUNCTION

The p75 neurotrophin receptor (p75NTR) was first identified in 1973 as the low-affinity nerve growth factor receptor (LNGFR) before discovery that p75NTR bound other neurotrophins equally well as nerve growth factor. p75NTR is a neurotrophic factor receptor. Neurotrophic factor receptors bind Neurotrophins including Nerve growth factor, Neurotrophin-3, Brain-derived neurotrophic factor, and Neurotrophin-4. All neurotrophins bind to p75NTR. This also includes the immature pro-neurotrophin forms. Neurotrophic factor receptors, including p75NTR, are responsible for ensuring a proper density to target ratio of developing neurons, refining broader maps in development into precise connections. p75NTR is involved in pathways that promote neuronal survival and neuronal death.