p53R2 Rabbit Polyclonal Antibody (HA500218)

UNIPROT #

Q7LG56

PROTEIN NAME

p53R2

SYNONYMS

DKFZp686M05248 antibody;MGC102856 antibody;MGC42116 antibody;MTDPS8A antibody;MTDPS8B antibody;p53 inducible ribonucleotide reductase small subunit 2 homolog antibody;p53 inducible ribonucleotide reductase small subunit 2 like protein antibody;P53 inducible ribonucleotide reductase small subunit 2 short form beta antibody;p53 R2 antibody;p53-inducible ribonucleotide reductase small subunit 2-like protein antibody;p53R2 antibody;Ribonucleoside diphosphate reductase M2 subunit B antibody;Ribonucleoside-diphosphate reductase subunit M2 B antibody;Ribonucleotide reductase M2 B (TP53 inducible) antibody;Ribonucleotide reductase M2 B antibody;Ribonucleotide reductase small subunit like 2 p53 inducible antibody;RIR2B_HUMAN antibody;RRM 2B antibody;RRM2B antibody;TP53 inducible ribonucleotide reductase M2 B antibody;TP53-inducible ribonucleotide reductase M2 B antibody

SUBCELLULAR LOCATION

Cytoplasm, Nucleus.

FUNCTION

This gene encodes the small subunit of a p53-inducible ribonucleotide reductase. This heterotetrameric enzyme catalyzes the conversion of ribonucleoside diphosphates to deoxyribonucleoside diphosphates. The product of this reaction is necessary for DNA synthesis. Mutations in this gene have been associated with autosomal recessive mitochondrial DNA depletion syndrome, autosomal dominant progressive external ophthalmoplegia-5, and mitochondrial neurogastrointestinal encephalopathy. Alternatively spliced transcript variants have been described.