p53 DINP1 Recombinant Rabbit Monoclonal Antibody [JG37-64] (ET7108-35)

UNIPROT #

Q96A56

PROTEIN NAME

p53 DINP1

SYNONYMS

DKFZp434M1317 antibody;FLJ22139 antibody;p53 damage inducible nuclear protein 1 antibody;p53 dependent damage inducible nuclear protein 1 antibody;p53 inducible nuclear protein 1 antibody;p53 inducible p53DINP1 antibody;p53-dependent damage-inducible nuclear protein 1 antibody;p53DINP1 antibody;SIP antibody;Stress induced protein antibody;Stress-induced protein antibody;T53I1_HUMAN antibody;Teap antibody;TP53 DINP1 antibody;TP53 INP1 antibody;TP53DINP1 antibody;TP53INP1 antibody;TP53INP1A antibody;TP53INP1B antibody;Tumor protein p53 inducible nuclear protein 1 antibody;Tumor protein p53-inducible nuclear protein 1 antibody

TISSUE SPECIFICITY

Ubiquitously expressed.

SUBCELLULAR LOCATION

Cytosol. Nucleus.

FUNCTION

Antiproliferative and proapoptotic protein involved in cell stress response which acts as a dual regulator of transcription and autophagy. Acts as a positive regulator of autophagy. In response to cellular stress or activation of autophagy, relocates to autophagosomes where it interacts with autophagosome-associated proteins GABARAP, GABARAPL1/L2, MAP1LC3A/B/C and regulates autophagy. Acts as an antioxidant and plays a major role in p53/TP53-driven oxidative stress response. Possesses both a p53/TP53-independent intracellular reactive oxygen species (ROS) regulatory function and a p53/TP53-dependent transcription regulatory function. Positively regulates p53/TP53 and p73/TP73 and stimulates their capacity to induce apoptosis and regulate cell cycle. In response to double-strand DNA breaks, promotes p53/TP53 phosphorylation on 'Ser-46' and subsequent apoptosis. Acts as a tumor suppressor by inducing cell death by an autophagy and caspase-dependent mechanism. Can reduce cell migration by regulating the expression of SPARC.