p50 dynamitin Rabbit Polyclonal Antibody (HA500029)

UNIPROT #

Q13561

PROTEIN NAME

p50 dynamitin

SYNONYMS

50 kD dynein associated polypeptide antibody;50 kDa dynein associated polypeptide antibody;50 kDa dynein-associated polypeptide antibody;DCTN-50 antibody;DCTN2 antibody;DCTN2_HUMAN antibody;DCTN50 antibody;dynactin 2 (p50) antibody;dynactin 2 antibody;dynactin complex 50 kD subunit antibody;Dynactin complex 50 kDa subunit antibody;Dynactin subunit 2 antibody;DYNAMITIN antibody;p50 dynamitin antibody;RBP50 antibody

SUBCELLULAR LOCATION

Cytoplasm, Cytoskeleton, Dynein, Membrane, Microtubule.

FUNCTION

This gene encodes a 50-kD subunit of dynactin, a macromolecular complex consisting of 23 subunits (11 individual proteins ranging in size from 22 to 150 kD). The subunit is commonly referred to as p50 or dynamitin. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present in 4 copies per dynactin molecule. It contains three short alpha-helical coiled-coil domains that bind to two copies of p150-glued (DCTN1) and two copies of p24 (DCTN3) to form the dynactin shoulder domain.