p40-phox Recombinant Rabbit Monoclonal Antibody [JE58-57] (HA720040)

UNIPROT #

Q15080

PROTEIN NAME

p40-phox

SYNONYMS

CGD3 antibody;MGC3810 antibody;NCF 4 antibody;NCF antibody;NCF-4 antibody;Ncf4 antibody;NCF4_HUMAN antibody;Neutrophil cytosol factor 4 antibody;Neutrophil cytosolic factor 4 antibody;Neutrophil NADPH oxidase factor 4 antibody;p40-phox antibody;p40phox antibody;SH3 and PX domain-containing protein 4 antibody;SH3PXD4 antibody

SUBCELLULAR LOCATION

Endosome membrane, Cytosol, Membrane.

FUNCTION

The protein encoded by this gene is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. This protein is preferentially expressed in cells of myeloid lineage. It interacts primarily with neutrophil cytosolic factor 2 (NCF2/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1/p47-phox), which further interacts with the small G protein RAC1 and translocates to the membrane upon cell stimulation. This complex then activates flavocytochrome b, the membrane-integrated catalytic core of the enzyme system. The PX domain of this protein can bind phospholipid products of the PI(3) kinase, which suggests its role in PI(3) kinase-mediated signaling events. The phosphorylation of this protein was found to negatively regulate the enzyme activity. Alternatively spliced transcript variants encoding distinct isoforms have been observed.