p38 alpha/MAPK14 + p38 beta/MAPK11 + p38 gamma/MAPK12 Recombinant Rabbit Monoclonal Antibody [PSH03-60] (HA722019)

UNIPROT #

Q16539

PROTEIN NAME

p38 alpha/MAPK14 + p38 beta/MAPK11 + p38 gamma/MAPK12

SYNONYMS

ERK 6 antibody;ERK-6 antibody;ERK6 antibody;Extracellular signal-regulated kinase 6 antibody;MAP kinase 12 antibody;MAP kinase p38 gamma antibody;MAPK 12 antibody;Mapk12 antibody;Mitogen Activated Protein Kinase 12 antibody;Mitogen activated protein kinase p38 gamma antibody;Mitogen-activated protein kinase 12 antibody;Mitogen-activated protein kinase p38 gamma antibody;MK12_HUMAN antibody;P38 GAMMA antibody;P38GAMMA antibody;PRKM12 antibody;SAPK 3 antibody;SAPK-3 antibody;SAPK3 antibody;Stress Activated Protein Kinase 3 antibody;Stress-activated protein kinase 3 antibody

SUBCELLULAR LOCATION

Cytoplasm, Nucleus, Mitochondrion.

FUNCTION

A mitogen-activated protein kinase (MAPK or MAP kinase) is a type of protein kinase that is specific to the amino acids serine and threonine (i.e., a serine/threonine-specific protein kinase). MAPKs are involved in directing cellular responses to a diverse array of stimuli, such as mitogens, osmotic stress, heat shock and proinflammatory cytokines. They regulate cell functions including proliferation, gene expression, differentiation, mitosis, cell survival, and apoptosis. MAP kinases are found in eukaryotes only, but they are fairly diverse and encountered in all animals, fungi and plants, and even in an array of unicellular eukaryotes. MAPKs belong to the CMGC (CDK/MAPK/GSK3/CLK) kinase group. The closest relatives of MAPKs are the cyclin-dependent kinases (CDKs).