Lane 1: SHSY5Y cell lysate
Lane 2: Jurkat cell lysate
Lane 3: Rat brain tissue lysate
Lane 4: Mouse brain tonsil tissue lysate
Rabbit polyclonal primary
P2X7 Rabbit Polyclonal Antibody (ER1901-99)
Synthetic peptide corresponding to c terminal rat p2x7.
SHSY5Y cell lysate, Jurkat cell lysate, rat brain tissue lysate, mouse brain tonsil tissue lysate, rat brain tissue, human kidney tissue, mouse brain tissue, THP-1.
Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Peptide affinity purified.
Predicted band size 68/58/49/36 kDa.
ATP receptor antibody; P2rx7 antibody; P2RX7_HUMAN antibody; P2X purinoceptor 7 antibody; P2X7 antibody; P2Z receptor antibody; Purinergic receptor antibody; purinergic receptor P2X, ligand gated ion channel, 7 antibody
Belongs to the P2X receptor family.
Widely expressed with highest levels in brain and immune tissues.
Phosphorylation results in its inactivation.; ADP-ribosylation at Arg-125 is necessary and sufficient to activate P2RX7 and gate the channel.; Palmitoylation of several cysteines in the C-terminal cytoplasmic tail is required for efficient localization to cell surface.
P2X purinoceptor 7 is a protein that in humans is encoded by the P2RX7 gene.The product of this gene belongs to the family of purinoceptors for ATP. Multiple alternatively spliced variants which would encode different isoforms have been identified although some fit nonsense-mediated decay criteria.The receptor is found in the central and peripheral nervous systems, in microglia, in macrophages, in uterine endometrium, and in the retina. The P2X7 receptor also serves as a pattern recognition receptor for extracellular ATP-mediated apoptotic cell death,regulation of receptor trafficking, mast cell degranulation, and inflammation. Receptor for ATP that acts as a ligand-gated ion channel. Responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Could function in both fast synaptic transmission and the ATP-mediated lysis of antigen-presenting cells. In the absence of its natural ligand, ATP, functions as a scavenger receptor in the recognition and engulfment of apoptotic cells