P2X6 Rabbit Polyclonal Antibody (ER1901-49)

UNIPROT #

O15547

PROTEIN NAME

P2X6

SYNONYMS

ATP receptor antibody;P2RX6 antibody;P2RX6_HUMAN antibody;P2RXL1 antibody;P2X purinoceptor 6 antibody;P2X6 antibody;P2XM antibody;Purinergic receptor antibody;Purinergic receptor P2X ligand gated ion channel 6 antibody;Purinergic receptor P2X like 1 antibody;Purinergic receptor P2X-like 1 antibody;Purinoceptor P2X6 antibody;Purinoreceptor P2X6 antibody;Skeletal muscle expressed P2X antibody

SEQUENCE SIMILARITIES

Belongs to the P2X receptor family.

TISSUE SPECIFICITY

Expressed predominantly in skeletal muscle.

POST-TRANSLATIONAL MODIFICATION

N-glycosylated.

SUBCELLULAR LOCATION

Membrane.

FUNCTION

P2X purinoceptor 6 is a protein that in humans is encoded by the P2RX6 gene. The P2X receptor family is comprised of ligand-gated ion channels that allow for the increased permeability of calcium into the cell in response to extracellular ATP. The seven P2X receptors, P2X1-P2X7, form either homomeric or heteromeric channels or both. They are characterized by intracellular amino- and carboxy-termini. P2X receptors are expressed in a wide variety of tissues, including neurons, prostate, bladder, pancreas, colon, testis and ovary. The major function of the P2X receptors is to mediate synaptic transmissions between neurons and to other tissues via the binding of extracellular ATP, which acts as a neurotransmitter. The P2X receptors may be involved in the onset of necrosis or apoptosis after prolonged exposure to high concentrations of extracellular ATP. The protein encoded by this gene belongs to the family of P2X receptors, which are ATP-gated ion channels and mediate rapid and selective permeability to cations. This gene is predominantly expressed in skeletal muscle, and regulated by p53. The encoded protein is associated with VE-cadherin at the adherens junctions of human umbilical vein endothelial cells.