Lane 1: Mouse brain tissue
Lane 2: SK-Br-3
Lane 3: Rat lung tissue
Recombinant Rabbit monoclonal primary
p23 Recombinant Rabbit Monoclonal Antibody [JU09-31] (ET1706-43)
Synthetic peptide within human p23 aa 43-92 / 160.
Mouse brain tissue lysate, SK-Br-3, rat lung tissue lysate, A431, Hela, human tonsil tissue, human colon cancer tissue, mouse fallopian tube tissue, rat testis tissue.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A purified.
Co chaperone p23 antibody; cPGES antibody; Cytosolic prostaglandin E synthase antibody; Cytosolic prostaglandin E2 synthase antibody; Hsp90 co chaperone antibody; Hsp90 co-chaperone antibody; P23 antibody; Progesterone receptor complex antibody; Progesterone receptor complex p23 antibody; Prostaglandin E synthase 3 (cytosolic) antibody; Prostaglandin E synthase 3 antibody; PTGES 3 antibody; PTGES3 antibody; Sid 3177 antibody; TEBP antibody; TEBP_HUMAN antibody; Telomerase binding protein p23 antibody; Telomerase-binding protein p23 antibody; Unactive progesterone receptor 23 kD antibody
Belongs to the p23/wos2 family.
P23, also known as PTGES3 (prostaglandin E synthase 3) or TEBP (telomerase-binding protein p23), is a ubiquitously expressed protein that functions as a cochaperone and plays an important role in signal transduction. One of several proteins in the HSP 90-based molecular chaperone complex, P23 promotes the breakdown of transcriptional regulatory complexes by disrupting receptor-mediated transcriptional activation. P23 acts in a hormone-dependent manner to chaperone estrogen receptor alpha (ERα), a steroid complex, to its mature form and to regulate the expression of ERα-related genes. Localized to the cytoplasm, P23 interacts with the glucocorticoid receptor (GR) and, through disassembly of the GR transcription machinery, is thought to inhibit GR-dependent transcription. The involvement of P23 in various steroid receptor-mediated pathways suggests close involvement in signal transduction and regulation of cellular processes. Upregulation of P23 is implicated in the invasion and metastasis of various cancers.