p23 Recombinant Rabbit Monoclonal Antibody [JU09-31] (ET1706-43)

UNIPROT #

Q15185

PROTEIN NAME

p23

SYNONYMS

Co chaperone p23 antibody;cPGES antibody;Cytosolic prostaglandin E synthase antibody;Cytosolic prostaglandin E2 synthase antibody;Hsp90 co chaperone antibody;Hsp90 co-chaperone antibody;P23 antibody;Progesterone receptor complex antibody;Progesterone receptor complex p23 antibody;Prostaglandin E synthase 3 (cytosolic) antibody;Prostaglandin E synthase 3 antibody;PTGES 3 antibody;PTGES3 antibody;Sid 3177 antibody;TEBP antibody;TEBP_HUMAN antibody;Telomerase binding protein p23 antibody;Telomerase-binding protein p23 antibody;Unactive progesterone receptor 23 kD antibody

SEQUENCE SIMILARITIES

Belongs to the p23/wos2 family.

SUBCELLULAR LOCATION

Cytoplasm.

FUNCTION

P23, also known as PTGES3 (prostaglandin E synthase 3) or TEBP (telomerase-binding protein p23), is a ubiquitously expressed protein that functions as a cochaperone and plays an important role in signal transduction. One of several proteins in the HSP 90-based molecular chaperone complex, P23 promotes the breakdown of transcriptional regulatory complexes by disrupting receptor-mediated transcriptional activation. P23 acts in a hormone-dependent manner to chaperone estrogen receptor alpha (ERα), a steroid complex, to its mature form and to regulate the expression of ERα-related genes. Localized to the cytoplasm, P23 interacts with the glucocorticoid receptor (GR) and, through disassembly of the GR transcription machinery, is thought to inhibit GR-dependent transcription. The involvement of P23 in various steroid receptor-mediated pathways suggests close involvement in signal transduction and regulation of cellular processes. Upregulation of P23 is implicated in the invasion and metastasis of various cancers.