P Glycoprotein Rabbit Polyclonal Antibody (HA500474)

UNIPROT #

P08183

PROTEIN NAME

P Glycoprotein

SYNONYMS

ABC20 antibody;ABCB1 antibody;ATP binding cassette, sub family B (MDR/TAP), member 1 antibody;ATP-binding cassette sub-family B member 1 antibody;CD243 antibody;CLCS antibody;Colchicin sensitivity antibody;Doxorubicin resistance antibody;GP170 antibody;MDR1 antibody;MDR1_HUMAN antibody;Multidrug resistance 1 antibody;Multidrug resistance protein 1 antibody;P glycoprotein 1 antibody;P gp antibody;P-glycoprotein 1 antibody;PGY1 antibody

SUBCELLULAR LOCATION

Cell membrane, Apical cell membrane.

FUNCTION

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. Mutations in this gene are associated with colchicine resistance and Inflammatory bowel disease 13. Alternative splicing and the use of alternative promoters results in multiple transcript variants.