OTULIN Rabbit Polyclonal Antibody (HA500587)

UNIPROT #

Q96BN8

PROTEIN NAME

OTULIN

SYNONYMS

AIPDS antibody;Deubiquitinating enzyme otulin antibody;F105B_HUMAN antibody;Fam105b antibody;Family with sequence similarity 105, member B antibody;FLJ34884 antibody;GUM antibody;OTU deubiquitinase with linear linkage specificity antibody;OTULIN antibody;Protein FAM105B antibody;Ubiquitin thioesterase Gumby antibody

SUBCELLULAR LOCATION

Cytoplasm.

FUNCTION

Deubiquitinase that specifically removes linear ('Met-1'-linked) polyubiquitin chains to substrates and acts as a regulator of angiogenesis and innate immune response. Required during angiogenesis, craniofacial and neuronal development by regulating the canonical Wnt signaling together with the LUBAC complex. Acts as a negative regulator of NF-kappa-B by regulating the activity of the LUBAC complex. OTULIN function is mainly restricted to homeostasis of the LUBAC complex: acts by removing 'Met-1'-linked autoubiquitination of the LUBAC complex, thereby preventing inactivation of the LUBAC complex. Acts as a key negative regulator of inflammation by restricting spontaneous inflammation and maintaining immune homeostasis. In myeloid cell, required to prevent unwarranted secretion of cytokines leading to inflammation and autoimmunity by restricting linear polyubiquitin formation. Plays a role in innate immune response by restricting linear polyubiquitin formation on LUBAC complex in response to NOD2 stimulation, probably to limit NOD2-dependent pro-inflammatory signaling.