OTC/Ornithine Carbamoyltransferase Rabbit Polyclonal Antibody (HA500048)
Catalog# HA500048
Rabbit Polyclonal to OTC/Ornithine Carbamoyltransferase
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WB
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IF-Cell
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IHC-P
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Human
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Mouse
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Rat
Positive control:
Lane 1: Rat colon tissue lysate
Lane 2: Human liver tissue lysate
Lane 2: Mouse liver tissue lysate
Specifications
Product Type
Rabbit polyclonal primary
Product Name
OTC/Ornithine Carbamoyltransferase Rabbit Polyclonal Antibody (HA500048)
Immunogen
Recombinant protein within human otc/ornithine carbamoyltransferase aa 200-354.
Host
Rabbit
Positive Control
Rat colon tissue lysate, human liver tissue lysate, mouse liver tissue lysate, SW480, human liver carcinoma tissue, human liver tissue.
Conjugation
Unconjugated
Clonality
Polyclonal
RRID
APPLICATION DILUTION
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WB
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1:1,000-1:5,000
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IF-Cell
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1:50-1:200
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IHC-P
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1:100-1:500
PROPERTIES
Form
Liquid
Storage Condition
Shipped at 4℃. Store at +4℃ short term (1-2 weeks). It is recommended to aliquot into single-use upon delivery. Store at -20℃ long term.
Storage Buffer
1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1ug/ul
Purification
Immunogen affinity purified.
Molecular Weight
40 kDa
Isotype
IgG
TARGET
UNIPROT #
PROTEIN NAME
OTC/Ornithine Carbamoyltransferase
SYNONYMS
EC 2.1.3.3 antibody;MGC129967 antibody;MGC129968 antibody;MGC138856 antibody;OCTD antibody;Ornithine Carbamoyltransferase antibody;Ornithine carbamoyltransferase mitochondrial antibody;Ornithine carbamoyltransferase, mitochondrial antibody;Ornithine transcarbamylase antibody;Otc antibody;OTC_HUMAN antibody;OTCase antibody
SUBCELLULAR LOCATION
Mitochondrion.
FUNCTION
Ornithine transcarbamylase (OTC) (also called ornithine carbamoyltransferase) is an enzyme (EC 2.1.3.3) that catalyzes the reaction between carbamoyl phosphate (CP) and ornithine (Orn) to form citrulline (Cit) and phosphate (Pi). There are two classes of OTC anabolic and catabolic. This article focuses on anabolic OTC. Anabolic OTC facilitates the sixth step in the biosynthesis of the amino acid arginine in prokaryotes.[5] In contrast, mammalian OTC plays an essential role in the urea cycle whose purpose is to capture toxic ammonia and transform it into less toxic urea nitrogen source for excretion.
CITATIONS
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Multi-dimensional metabolomic profiling reveals dysregulated ornithine metabolism hallmarks associated with a severe acute pancreatitis phenotype
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IHC
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Mouse
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Citation
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