Recombinant production enables lot-to-lot consistency and is animal-cruelty-free
Western blot analysis of OS9 on different lysates. Proteins were transferred to a PVDF membrane and blocked with 5% BSA in PBS for 1 hour at room temperature. The primary antibody (ET7108-61, 1/500) was used in 5% BSA at room temperature for 2 hours. Goat Anti-Rabbit IgG - HRP Secondary Antibody (HA1001) at 1:200,000 dilution was used for 1 hour at room temperature.
Lane 1: Mouse testis tissue lysate
Lane 2: Rat testis tissue lysate
Amplified in osteosarcoma 9 antibody;amplified in osteosarcoma antibody;ERLEC2 antibody;OS-9 antibody;Os9 antibody;OS9_HUMAN antibody;Osteosarcoma amplified 9 endoplasmic reticulum lectin antibody;Protein OS-9 antibody
Belongs to the OS-9 family.
Ubiquitously expressed. Found as well in all tumor cell lines analyzed, amplified in sarcomas. Highly expressed in osteosarcoma SJSA-1 and rhabdomyosarcoma Rh30 cell lines. Isoform 2 is the major isoform detected in all cell types examined.
Intramolecular disulfide bonds.; Isoform 1 and isoform 2 are N-glycosylated.
Protein OS-9 is a protein that in humans is encoded by the OS9 gene.This gene encodes a protein that is highly expressed in osteosarcomas. This protein binds to the hypoxia-inducible factor 1 (HIF-1), a key regulator of the hypoxic response and angiogenesis, and promotes the degradation of one of its subunits. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Just like the interactions between antigens and antibodies, the higher the affinity between you and us the better.