Alpha 1 Acid Glycoprotein Mouse Monoclonal Antibody [A2-B10] (EM1510-41)

UNIPROT #

P02763

PROTEIN NAME

Alpha 1 Acid Glycoprotein

SYNONYMS

A1AG1_HUMAN antibody;AGP 1 antibody;AGP A antibody;AGP antibody;AGP1 antibody;Alpha 1 acid glycoprotein antibody;Alpha-1-acid glycoprotein 1 antibody;alpha-1-AGP antibody;Epididymis secretory sperm binding protein Li 153w antibody;glycoprotein, alpha-1-acid, of serum antibody;HEL S 153w antibody;OMD 1 antibody;ORM antibody;ORM1 antibody;Orosomucoid 1 antibody;Orosomucoid-1 antibody

SEQUENCE SIMILARITIES

Belongs to the calycin superfamily. Lipocalin family.

TISSUE SPECIFICITY

Expressed by the liver and secreted in plasma.

POST-TRANSLATIONAL MODIFICATION

N-glycosylated. N-glycan heterogeneity at Asn-33: Hex5HexNAc4 (minor), Hex6HexNAc5 (major) and dHex1Hex6HexNAc5 (minor).

SUBCELLULAR LOCATION

Secreted.

FUNCTION

This gene encodes a key acute phase plasma protein. Because of its increase due to acute inflammation, this protein is classified as an acute-phase reactant. The specific function of this protein has not yet been determined; however, it may be involved in aspects of immunosuppression. Functions as transport protein in the blood stream. Binds various ligands in the interior of its beta-barrel domain. Also binds synthetic drugs and influences their distribution and availability in the body. Appears to function in modulating the activity of the immune system during the acute-phase reaction.