Rabbit polyclonal primary
Orai1 Rabbit Polyclonal Antibody (ER1803-11)
Synthetic peptide within mouse orai1 aa 181-230 / 304.
PC-3M, LOVO, MCF-7, human skin tissue, human esophagus tissue.
Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Peptide affinity purified.
Calcium release activated calcium channel protein 1 antibody; Calcium release activated calcium modulator 1 antibody; Calcium release-activated calcium channel protein 1 antibody; CRACM 1 antibody; CRACM1 antibody; CRCM1 antibody; CRCM1_HUMAN antibody; FLJ14466 antibody; Orai 1 antibody; ORAI calcium release activated calcium modulator 1 antibody; orai1 antibody; ORAT1 antibody; Protein orai 1 antibody; Protein orai-1 antibody; TMEM 142A antibody; TMEM142A antibody; Transmembrane protein 142A antibody
Belongs to the Orai family.
Expressed in naive CD4 and CD8 T cells (at protein level). Expressed at similar levels in naive and effector T helper cells.
N-glycosylated. N-glycosylation inhibits channel activity in T cells.; Ubiquitinated.; Cys-195 is oxidated, leading to inactivation of channel activity.
Orai1 (ORAI calcium release-activated calcium modulator 1), also known as ORAT1, CRACM1 (calcium release-activated calcium modulator 1) or TMEM142A (transmembrane protein 142A), is a 301 amino acid multi-pass membrane protein that belongs to the Orai family of proteins. Localizing to the plasma membrane, Orai1 plays an important role in store-operated calcium (SOC) entry, a process involving Ca2+ influx and replenishment of Ca2+ stores formerly emptied through the action of inositol 1,4,5-trisphosphate production and other Ca2+ mobilizing agents. Specifically, Orai1 functions as a pore subunit of the store-operated calcium release-activated calcium channel (CRAC) and is essential for proper function of the CRAC channel. CRAC channels are responsible for mediating calcium influx in T-cells and play an important role in the immune response. Mutations in the gene encoding Orai1 can result in severe combined immunodeficiency (SCID).