Nucleostemin Recombinant Rabbit Monoclonal Antibody [JG37-82] (ET7108-55)

UNIPROT #

Q9BVP2

PROTEIN NAME

Nucleostemin

SYNONYMS

C77032 antibody;E2 induced gene 3 protein antibody;E2-induced gene 3 protein antibody;E2IG3 antibody;Estradiol induced nucleotide binding protein antibody;GNL3 antibody;GNL3_HUMAN antibody;Guanine nucleotide binding protein like 3 (nucleolar) antibody;Guanine nucleotide binding protein like 3 antibody;Guanine nucleotide-binding protein-like 3 antibody;MGC800 antibody;NNP47 antibody;Novel nucleolar protein 47 antibody;NS antibody;Nucleolar GTP binding protein 3 antibody;Nucleolar GTP-binding protein 3 antibody;Nucleostemin antibody;Putative nucleotide binding protein estradiol induced antibody

SEQUENCE SIMILARITIES

Belongs to the TRAFAC class YlqF/YawG GTPase family.

TISSUE SPECIFICITY

Increased levels in lung tissue in cancer patients.

SUBCELLULAR LOCATION

Nucleus.

FUNCTION

The protein encoded by this gene may interact with p53 and may be involved in tumorigenesis. The encoded protein also appears to be important for stem cell proliferation. Stabilizes MDM2 by preventing its ubiquitination, and hence proteasomal degradation. This protein is found in both the nucleus and nucleolus. Three transcript variants encoding two different isoforms have been found for this gene.