Nucleoporin p62 Rabbit Polyclonal Antibody (ER2001-57)

UNIPROT #

P37198

PROTEIN NAME

Nucleoporin p62

SYNONYMS

62 kDa nucleoporin antibody;DKFZp547L134 antibody;FLJ20822 antibody;FLJ43869 antibody;IBSN antibody;MGC841 antibody;Nuclear pore glycoprotein p62 antibody;nucleoporin 62kDa antibody;Nucleoporin Nup62 antibody;nucleoporin p62 antibody;nucleoporin p62KD antibody;NUP62 antibody;NUP62 protein antibody;p62 antibody;SNDI antibody

SUBCELLULAR LOCATION

Cytoplasm, Cytoskeleton, Nuclear pore complex, Nucleus.

FUNCTION

The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene is a member of the FG-repeat containing nucleoporins and is localized to the nuclear pore central plug. This protein associates with the importin alpha/beta complex which is involved in the import of proteins containing nuclear localization signals. Multiple transcript variants of this gene encode a single protein isoform. The N-terminal is probably involved in nucleocytoplasmic transport. The C-terminal is involved in protein-protein interaction probably via coiled-coil formation, promotes its association with centrosomes and may function in anchorage of p62 to the pore complex. Plays a role in mitotic cell cycle progression by regulating centrosome segregation, centriole maturation and spindle orientation. It might be involved in protein recruitment to the centrosome after nuclear breakdown.