Nucleolin Rabbit Polyclonal Antibody (R1307-2)

UNIPROT #

P19338

PROTEIN NAME

Nucleolin

SYNONYMS

C23 antibody;FLJ45706 antibody;MS1116 antibody;NCL antibody;Nucl antibody;NUCL_HUMAN antibody;Nucleolin antibody;Protein C23 antibody

POST-TRANSLATIONAL MODIFICATION

Some glutamate residues are glycylated by TTLL8. This modification occurs exclusively on glutamate residues and results in a glycine chain on the gamma-carboxyl group (By similarity).; Symmetrically methylated by PRMT5.

SUBCELLULAR LOCATION

Nucleus, nucleolus, Cytoplasm.

FUNCTION

Nucleolin is a protein that in humans is encoded by the NCL gene. Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats. Nucleolin is also able to act as a transcriptional coactivator with Chicken Ovalbumin Upstream Promoter Transcription Factor II (COUP-TFII).