NSE Rabbit Polyclonal Antibody (R1401-6)

UNIPROT #

P09104

PROTEIN NAME

NSE

SYNONYMS

2 phospho D glycerate hydrolyase antibody;2-phospho-D-glycerate hydro-lyase antibody;Eno 2 antibody;ENO2 antibody;ENOG antibody;ENOG_HUMAN antibody;Enolase 2 (gamma, neuronal) antibody;Enolase 2 antibody;Enolase 2 gamma neuronal antibody;Enolase2 antibody;Epididymis secretory protein Li 279 antibody;Gamma enolase antibody;Gamma-enolase antibody;HEL S 279 antibody;Neural enolase antibody;Neuron specific enolase antibody;Neuron specific gamma enolase antibody;Neuron-specific enolase antibody;neuronal enriched enolase antibody;Neurone specific enolase antibody;NSE antibody

SEQUENCE SIMILARITIES

Belongs to the enolase family.

TISSUE SPECIFICITY

The alpha/alpha homodimer is expressed in embryo and in most adult tissues. The alpha/beta heterodimer and the beta/beta homodimer are found in striated muscle, and the alpha/gamma heterodimer and the gamma/gamma homodimer in neurons.

DEVELOPMENTAL STAGE

During ontogenesis, there is a transition from the alpha/alpha homodimer to the alpha/beta heterodimer in striated muscle cells, and to the alpha/gamma heterodimer in nerve cells.

SUBCELLULAR LOCATION

Cytoplasm, cell membrane

FUNCTION

Gamma-enolase is one of the three enolase isoenzymes found in mammals. This isoenzyme, a homodimer, is found in mature neurons and cells of neuronal origin. A switch from alpha enolase to gamma enolase occurs in neural tissue during development in rats and primates. Detection of NSE with antibodies can be used to identify neuronal cells and cells with neuroendocrine differentiation. NSE is produced by small cell carcinomas which are neuroendocrine in origin. NSE is therefore a useful tumor marker for lung cancer patients.