NM23 Rabbit Polyclonal Antibody (R1603-3)

UNIPROT #

P15531

PROTEIN NAME

NM23

SYNONYMS

AWD antibody;AWD, drosophila, homolog of antibody;GAAD antibody;Granzyme A activated DNase antibody;Granzyme A-activated DNase antibody;GZMA activated DNase antibody;Metastasis inhibition factor NM23 antibody;NB antibody;NBS antibody;NDK A antibody;NDKA antibody;NDKA_HUMAN antibody;NDP kinase A antibody;NDPK-A antibody;NDPKA antibody;NM23 antibody;NM23 long variant, included antibody;nm23-H1 antibody;NM23-M1 antibody;NM23H1B, included antibody;NME/NM23 nucleoside diphosphate kinase 1 antibody;Nme1 antibody;NME1-NME2 spliced read-through transcript, included antibody;Non-metastatic cells 1, protein (NM23A) expressed in antibody;Nonmetastatic cells 1, protein expressed in antibody;Nonmetastatic protein 23 antibody;Nonmetastatic protein 23, homolog 1 antibody;Nucleoside diphosphate kinase A antibody;Tumor metastatic process-associated protein antibody

SEQUENCE SIMILARITIES

Belongs to the NDK family.

TISSUE SPECIFICITY

Isoform 1 is expressed in heart, brain, placenta, lung, liver, skeletal muscle, pancreas, spleen and thymus. Expressed in lung carcinoma cell lines but not in normal lung tissues. Isoform 2 is ubiquitously expressed and its expression is also related to tumor differentiation.

SUBCELLULAR LOCATION

Cytoplasm. Nucleus. 

FUNCTION

The nm23 gene, a potential suppressor of metastasis, was originally identified by differential hybridization between two murine melanoma sub-lines, one with a high and the second with a low metastatic capacity. Highly metastatic sub-lines exhibit much lower levels of nm23 than less metastatic cells. Based on sequence analysis, nm23 appears highly related to nucleotide diphosphate kinases (NDP). In humans, NDP kinases A and B are identical to two isotypes of human nm23 homologs, namely nm23-H1 and H2, respectively. nm23-H2 is identical in sequence to PuF, a transcription factor that binds to nuclease-hypersensitive elements at positions 142 to 115 of the human C-Myc promotor.