NM23 Mouse Monoclonal Antibody [12A1] (EM1801-20)

UNIPROT #

P15531

PROTEIN NAME

NM23

SYNONYMS

AWD antibody;AWD, drosophila, homolog of antibody;GAAD antibody;Granzyme A activated DNase antibody;Granzyme A-activated DNase antibody;GZMA activated DNase antibody;Metastasis inhibition factor NM23 antibody;NB antibody;NBS antibody;NDK A antibody;NDKA antibody;NDKA_HUMAN antibody;NDP kinase A antibody;NDPK-A antibody;NDPKA antibody;NM23 antibody;NM23 long variant, included antibody;nm23-H1 antibody;NM23-M1 antibody;NM23H1B, included antibody;NME/NM23 nucleoside diphosphate kinase 1 antibody;Nme1 antibody;NME1-NME2 spliced read-through transcript, included antibody;Non-metastatic cells 1, protein (NM23A) expressed in antibody;Nonmetastatic cells 1, protein expressed in antibody;Nonmetastatic protein 23 antibody;Nonmetastatic protein 23, homolog 1 antibody;Nucleoside diphosphate kinase A antibody;Tumor metastatic process-associated protein antibody

SEQUENCE SIMILARITIES

Belongs to the NDK family.

TISSUE SPECIFICITY

Isoform 1 is expressed in heart, brain, placenta, lung, liver, skeletal muscle, pancreas, spleen and thymus. Expressed in lung carcinoma cell lines but not in normal lung tissues. Isoform 2 is ubiquitously expressed and its expression is also related to tumor differentiation.

SUBCELLULAR LOCATION

Cytoplasm, Nucleus.

FUNCTION

Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3'-5' exonuclease activities. Involved in cell proliferation, differentiation and development, signal transduction, G protein-coupled receptor endocytosis, and gene expression. Required for neural development including neural patterning and cell fate determination. During GZMA-mediated cell death, works in concert with TREX1. NME1 nicks one strand of DNA and TREX1 removes bases from the free 3' end to enhance DNA damage and prevent DNA end reannealing and rapid repair. Mutations in this gene have been identified in aggressive neuroblastomas. Two transcript variants encoding different isoforms have been found for this gene. Co-transcription of this gene and the neighboring downstream gene (NME2) generates naturally-occurring transcripts (NME1-NME2), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product.