NK-p44 Recombinant Rabbit Monoclonal Antibody [JE61-04] (HA720070)

UNIPROT #

O95944

PROTEIN NAME

NK-p44

SYNONYMS

Activating NK receptor NKp44 antibody;CD336 antibody;CD336 antigen antibody;dJ149M18.1 antibody;LY95 antibody;Lymphocyte antigen 95 (activating NK receptor; NK p44) antibody;Lymphocyte antigen 95 homolog (activating NK receptor; NK p44) antibody;Lymphocyte antigen 95 homolog antibody;Lymphocyte antigen 95, mouse, homolog of antibody;Natural cytotoxicity triggering receptor 2 antibody;Natural killer cell p44 related protein antibody;Natural killer cell p44-related protein antibody;NCR2 antibody;NCTR2_HUMAN antibody;NK cell activating receptor (NKp44) antibody;NK cell activating receptor antibody;NK cell-activating receptor antibody;NK p44 antibody;NK-p44 antibody;NKp44 antibody

SUBCELLULAR LOCATION

Cell membrane.

FUNCTION

Natural killer (NK) cells direct cytotoxicity against tumor or virally infected cells. NK cell-mediated cytotoxicity is stimulated by several activating receptors associated with the signaling adapter DNAX activation 12/killer cell-activating receptor-associated protein (DAP12). NKp44 is a natural cytotoxicity receptor that is is expressed on IL-2-activated human NK cells and may contribute to the increased efficiency of NK cells to mediate tumor cell lysis. NKp44 is composed of one Ig-like extracellular domain, a transmembrane segment, and a cytoplasmic domain. Prolactin up-regulates and cortisol down-regulates the surface expression of NKp44 at the transcriptional level. A cellular ligand for NKp44 (NKp44L) is expressed during HIV-1 infection and is correlated with the progression of CD4+ T cell depletion and an increase of viral load. This implicates NKp44 as a therapeutic agent that may aid in the progress towards a vaccine for HIV-1 infection.