Nicastrin Recombinant Rabbit Monoclonal Antibody [JG68-33] (ET7108-38)

UNIPROT #

Q92542

PROTEIN NAME

Nicastrin

SYNONYMS

Anterior pharynx defective 2 antibody;APH 2 antibody;APH2 antibody;ATAG1874 antibody;KIAA0253 antibody;Ncstn antibody;NCT antibody;NICA_HUMAN antibody;Nicastrin antibody;RP11 517F10.1 antibody;RP11517F101 antibody

SEQUENCE SIMILARITIES

Belongs to the nicastrin family.

TISSUE SPECIFICITY

Detected in brain (at protein level). Widely expressed.

POST-TRANSLATIONAL MODIFICATION

N-glycosylated.

SUBCELLULAR LOCATION

Membrane.

FUNCTION

The Presenilin 1 (PS1) and Presenilin 2 (PS2) transmembrane proteins are components of high molecular weight complexes. These complexes mediate proteolytic cleavage within the transmembrane domain of several proteins, including the β-Amyloid precursor protein (βAPP) and Notch. Missense mutations in the genes encoding the Presenilin proteins increase the proteolysis of βAPP and results in the overproduction of the neurotoxic β-Amyloid peptide, which results in a condition associated with Familial Alzheimer's disease (FAD). A novel component of the presenilin complex, nicastrin, is a type I transmembrane glycoprotein that is involved in mediating Notch/GLP-1 signaling. In addition, nicastrin contributes to the processing of βAPP, which makes nicastrin an attractive potential target for modulating the production of β-Amyloid in patients with Alzheimer's disease. Originally purified from immunoprecipitated PS1 complexes from HEK293 cells, nicastrin contains hydrophilic amino and carboxy-terminal domains, a short, hydrophobic transmembrane domain and potential N-myristoylation and phosphorylation sites.