NGF Rabbit Polyclonal Antibody (ER1802-59)

UNIPROT #

P01138

PROTEIN NAME

NGF

SYNONYMS

Beta nerve growth factor antibody;Beta NGF antibody;Beta-nerve growth factor antibody;Beta-NGF antibody;HSAN5 antibody;MGC161426 antibody;MGC161428 antibody;Nerve growth factor (beta polypeptide) antibody;Nerve growth factor antibody;Nerve growth factor beta antibody;Nerve growth factor beta polypeptide antibody;Nerve growth factor beta subunit antibody;NGF antibody;NGF_HUMAN antibody;NGFB antibody;NID67 antibody

SEQUENCE SIMILARITIES

Belongs to the NGF-beta family.

SUBCELLULAR LOCATION

Secreted, Endosome lumen.

FUNCTION

Nerve growth factor (NGF) is a neurotrophic factor and neuropeptide primarily involved in the regulation of growth, maintenance, proliferation, and survival of certain target neurons. It is perhaps the prototypical growth factor, in that it was one of the first to be described. Since it was first isolated by Nobel Laureates Rita Levi-Montalcini and Stanley Cohen in 1956, numerous biological processes involving NGF have been identified, two of them being the survival of pancreatic beta cells and the regulation of the immune system. As its name suggests, NGF is involved primarily in the growth, as well as the maintenance, proliferation, and survival of nerve cells (neurons). In fact, NGF is critical for the survival and maintenance of sympathetic and sensory neurons, as they undergo apoptosis in its absence. However, several recent studies suggest that NGF is also involved in pathways besides those regulating the life cycle of neurons.