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NF-M Recombinant Antibody [JM11-20] - Guinea pig IgG2 (Chimeric) - BSA and Azide free (HA610279)

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Catalog# HA610279

to NF-M

Tested for

  • IHC-Fr

  • WB

Reacts with

  • Mouse

  • Rat

Recombinant production enables lot-to-lot consistency and is animal-cruelty-free

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Specifications

Product Type

Recombinant Chimeric Antibody primary

Product Name

NF-M Recombinant Antibody [JM11-20] - Guinea pig IgG2 (Chimeric) - BSA and Azide free (HA610279)

Immunogen

Synthetic peptide within human nefm aa 651-692 / 916.

Positive Control

Mouse cerebellum tissue, Rat cerebellum tissue, Mouse brain tissue lysate, Rat brain tissue lysate.

Conjugation

Unconjugated

Clone Number

JM11-20

APPLICATION DILUTION

  • IHC-Fr

  • 1:500

  • WB

  • 1:5,000

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.

Storage Buffer

1*PBS (pH7.4).

Concentration

1ug/ul

Purification

Protein A affinity purified.

Molecular Weight

Predicted band size: 102 kDa

TARGET

UNIPROT #

P08553

PROTEIN NAME

NF-M

SYNONYMS

150kDa medium antibody;NEF3 antibody;NEFM antibody;Neurofilament 3 antibody;NF160 antibody;NFM antibody

SUBCELLULAR LOCATION

Cell projection, Cytoplasm, Cytoskeleton, Intermediate filament.

FUNCTION

Neurofilament-M (NF-M), for neurofilament medium polypeptide, a member of the intermediate filament family, is a major component of neuronal cytoskeletons. Neurofilaments are dynamic structures; they contain phosphorylation sites for a large number of protein kinases, including protein kinase A, protein kinase C, cyclin-dependent kinase 5, extracellular signal regulated kinase, glycogen synthase kinase-3, and stress-activated protein kinase gamma. In addition to their role in the control of axon caliber, neurofilaments may affect other cytoskeletal elements, such as microtubules and actin filaments. Changes in neurofilament phosphorylation or metabolism are frequently observed in neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS), Parkinson's disease, and Alzheimer's disease.

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