Lane 1: human brain tissue lysate
Lane 2: rat brain tissue lysate
Lane 2: mouse brain tissue lysate
Recombinant Rabbit monoclonal primary
NeuN Recombinant Rabbit Monoclonal Antibody [SR45-07] (ET1602-12)
Synthetic peptide within human neun aa 20-60.
Human brain tissue lysate, rat brain tissue lysate, mouse brain tissue lysate, SH-SY5Y, mouse brain tissue, mouse cerebellum tissue, rat brain tissue, human brain tissue.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A affinity purified.
FLJ56884 antibody; FLJ58356 antibody; Fox-1 homolog C antibody; fox1 homolog C antibody; Fox3 antibody; FOX3NeuN antibody; hexaribonucleotide binding protein 3 antibody; HRNBP3 antibody; NEUN antibody; neuronal nuclei antibody; Rbfox3 antibody; RFOX3_HUMAN antibody; RNA binding protein fox-1 homolog 3 antibody; RNA binding protein, fox 1 homolog (C. elegans) 3 antibody; hide
Neuronal nuclei (NeuN, Fox-3, RBFOX3) is a nuclear protein expressed in most post-mitotic neurons of the central and peripheral nervous systems. NeuN is not detected in Purkinje cells, sympathetic ganglion cells, Cajal-Retzius cells, INL retinal cells, inferior olivary, and dentate nucleus neurons. This neuronal protein was originally identified by immunoreactivity with a monoclonal antibody also called NeuN. Using MS-analysis, NeuN was later identified as the Fox-3 gene product. Fox-3 contains an RNA recognition motif and functions as a splicing regulator. Fox-3 regulates alternative splicing of NumB, promoting neuronal differentiation during development.
Wang, H., Huang, M., Wan......
Wang, H., Huang, M., Wang, W., Zhang, Y., Ma, X., Luo, L., Xu, X., Xu, L., Shi, H., Xu, Y., Wang, A., & Xu, T. (2021). Microglial TLR4-induced TAK1 phosphorylation and NLRP3 activation mediates neuroinflammation and contributes to chronic morphine-induced antinociceptive tolerance. Pharmacological research, 165, 105482.